{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:27:18Z","timestamp":1786562838580,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human papillomavirus (HPV) is one of the primary causes of oropharyngeal squamous cell carcinoma (OPSCC), accounting for around 70% of cases in high\u2010income countries. In Denmark, OPSCC is the most common head and neck cancer, yet public awareness of HPV's role has not been assessed in Denmark. This study aims to assess HPV awareness and estimate the future disease and economic burden of OPSCC in Denmark. A nationally representative cross\u2010sectional survey of 559 Danish adults was conducted in January 2025 to evaluate awareness of HPV, its link to OPSCC, and perceptions of vaccination. Age\u2010adjusted incidence rates were calculated from the Danish Cancer Registry (1980\u20132021) and projected to 2039 and used to estimate the economic burden from treatment costs and productivity losses. Between 1980 and 2021, the incidence of OPSCC increased 7.3\u2010fold in Denmark. Projections indicate that by 2039, the incidence among men will reach 12.3 cases (95% CI 11.7\u201312.8) per 100,000 population. The cumulative economic burden of OPSCC from 2025 to 2039 is estimated at \u20ac2.23 billion (95% CI 2.12\u20132.33), with productivity losses accounting for the majority of costs. Despite the prevalence and economic impact, public awareness of HPV and its association with OPSCC remains limited in Denmark. Among survey respondents, 38.5% had never heard of HPV, and only 37.0% recognized its link to OPSCC. These findings underscore the urgent need for comprehensive public education, awareness initiatives, and strengthened early detection initiatives to curb the rising incidence and substantial economic impact of HPV\u2010associated OPSCC in Denmark.<\/jats:p>","DOI":"10.1002\/ijc.70477","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T04:29:11Z","timestamp":1775622551000},"page":"566-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Awareness of Human Papillomavirus (\n                    <scp>HPV<\/scp>\n                    ), Increasing Rates of Oropharyngeal Cancer, and Estimated Economic Burden in Denmark"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0336-5411","authenticated-orcid":false,"given":"Kathrine Kronberg","family":"Jakobsen","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery &amp; Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umar","family":"Rehman","sequence":"additional","affiliation":[{"name":"UCL Division of Surgery and Interventional Science University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gr\u00f8nh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery &amp; Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Jian","family":"Lau","sequence":"additional","affiliation":[{"name":"UCL Division of Surgery and Interventional Science University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Peter","family":"Klussmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Lechner","sequence":"additional","affiliation":[{"name":"UCL Division of Surgery and Interventional Science University College London  London UK"},{"name":"UCL Cancer Institute University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery &amp; Audiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Danish Head and Neck Cancer Group (DAHANCA) \u201c\u00c5rsrapport 2023 for den kliniske kvalitetsdatabase DAHANCA \u201d [Annual Report 2023 for the Clinical Quality Database DAHANCA] 2023."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00603-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.35099"},{"key":"e_1_2_10_5_1","unstructured":"Statens Serum Institut \u201cDet danske b\u00f8rnevaccinationsprogram \u201d [The Danish Chilhood Vaccination Program] 2022 https:\/\/www.ssi.dk\/vaccinationer\/boernevaccination."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13071339"},{"key":"e_1_2_10_7_1","unstructured":"\u201cN\u00e6sten alle b\u00f8rn f\u00f8lger b\u00f8rnevaccinationsprogrammet i Danmark | Sundhedsstyrelsen \u201dhttps:\/\/www.sst.dk\/da\/nyheder\/2024\/Naesten\u2010alle\u2010boern\u2010foelger\u2010boernevaccinationsprogrammet\u2010i\u2010Danmark."},{"key":"e_1_2_10_8_1","unstructured":"\u201cTilslutning til b\u00f8rnevaccinationsprogrammet \u201dhttps:\/\/www.ssi.dk\/vaccinationer\/tilslutning\u2010til\u2010bornevaccinationsprogrammet."},{"key":"e_1_2_10_9_1","unstructured":"\u201cHPV drenge f\u00e6rdigvacc. 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