{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:47:56Z","timestamp":1783453676341,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Synovial sarcoma (SS) is a rare and aggressive soft tissue sarcoma frequently associated with lung metastases. While anthracycline plus ifosfamide (AI) remains a standard first\u2010line regimen, its benefit in SS patients with lung metastases is unknown. Anlotinib, a multi\u2010target tyrosine kinase inhibitor (TKI), has shown promising effects in sarcoma treatment, but its combination with AI has not been well studied in this setting. This retrospective, single\u2010center study included 108 SS patients with lung metastases treated between 2007 and 2024, receiving either AI alone (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200959) or AI combined with anlotinib (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200949). Survival outcomes were assessed using Kaplan\u2013Meier analysis, and adverse events (AEs) were reviewed from clinical records. The results indicated that the combination therapy demonstrated statistically significant improvements in clinical outcomes compared to AI monotherapy, with a median PFS of 8.1\u2009months versus 6.2\u2009months (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0250), and a median OS of 14.8 months versus 6.8\u2009months (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0033). Most AEs were Grades 1\u20132 according to common terminology criteria for adverse events (CTCAE) criteria, with manageable toxicity profiles. The combination group exhibited modest but clinically insignificant elevations in hypertension and proteinuria, with no reported treatment\u2010related mortality. In conclusion, the anlotinib and AI chemotherapy combination regimen shows promising efficacy in prolonging survival duration for SS patients with lung metastases while maintaining an acceptable safety profile. These findings suggest that this combination therapy could be considered as a viable first\u2010line treatment option for this patient population, warranting further validation through phase III randomized controlled trials.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70501","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:36:56Z","timestamp":1776260216000},"page":"1274-1281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy and Safety of\n                    <scp>AI<\/scp>\n                    With Anlotinib Versus\n                    <scp>AI<\/scp>\n                    for Treating Synovial Sarcoma Patients With Lung Metastasis: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2853-2813","authenticated-orcid":false,"given":"Yangbai","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3466-0175","authenticated-orcid":false,"given":"Xuesi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital Fudan University  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