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After 4 induction cycles, the overall response rate and complete response rate were 97.2% and 80.6%, respectively. With a median follow\u2010up of 19.9\u2009months, the 2\u2010year progression\u2010free survival (PFS) and overall survival rates were 64.4% and 79.3%. The 2\u2010year PFS was 100% in patients receiving sequential autologous stem cell transplantation (ASCT), 67.9% with maintenance therapy (BTKi\/IMiD), and 45.5% with induction only. The most common Grades 3\u20134 adverse event was neutropenia (33.3%); all were manageable without treatment discontinuation. These findings indicate that the RMT regimen demonstrates excellent efficacy and a favorable safety profile in PCNS\u2010DLBCL, including elderly patients; sequential ASCT is the preferred consolidation strategy, while BTKi\/IMiD maintenance provides a viable alternative for sustained disease control.<\/jats:p>","DOI":"10.1002\/ijc.70507","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T09:54:59Z","timestamp":1776506099000},"page":"1499-1509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety Profile of a Rituximab, Methotrexate, and Thiotepa\u2010Based Regimen in Newly Diagnosed Primary\n                    <scp>CNS<\/scp>\n                    Lymphoma"],"prefix":"10.1002","volume":"159","author":[{"given":"Haotian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology The First Hospital of Jilin University  ChangChun Jilin 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