{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:04:05Z","timestamp":1784887445817,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005941","name":"Dietmar Hopp Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immune checkpoint inhibitors have shown promising results in the neoadjuvant treatment of resectable non\u2010small cell lung cancer. This open\u2010label, single\u2010arm, prospective, monocentric trial evaluated the efficacy and safety of neoadjuvant atezolizumab plus carboplatin\/nab\u2010paclitaxel in patients with resectable non\u2010squamous non\u2010small cell lung cancer. Patients with previously untreated, pathologically confirmed, non\u2010squamous non\u2010small cell lung cancer in stage II, IIIA, and select IIIB (T3N2 only) were treated with atezolizumab and carboplatin\/nab\u2010paclitaxel for 3\u2009cycles followed by curative intent surgery. Major pathologic response (MPR) was defined as primary endpoint. 20 patients with histologically confirmed pulmonary adenocarcinoma in TNM\u2010stage IIA (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091, 5%), stage IIB (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097, 35%), and stage IIIA (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912, 60%) were enrolled and treated according to the study protocol. 151 treatment\u2010related adverse events were recorded, and 13 patients (65%) had treatment\u2010related adverse events of grade 3 or higher. There were no grade 5 events. All patients underwent complete anatomical resection (R0). MPR was observed in 9 patients (45%), including 5 (25%) patients with complete pathological response. The proportion of remaining viable tumor showed a significant but weak association to the relative tumor size change in CT (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.018) and the relative change in SUV\n                    <jats:sub>max<\/jats:sub>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006). In conclusion, neoadjuvant chemoimmunotherapy with atezolizumab achieved a promising MPR\u2010rate of 45% while being well tolerated and allowing a safe and complete surgical resection. These results strongly support the further investigation of atezolizumab as preoperative therapy in resectable non\u2010small cell lung cancer and underline the continued need to develop biomarkers of response.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70508","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:42:47Z","timestamp":1776667367000},"page":"1510-1520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoadjuvant Atezolizumab and Chemotherapy for Non\u2010Squamous Non\u2010Small Cell Lung Cancer: Efficacy and Safety Results of an Open\u2010Label, Single\u2010Arm, Phase\n                    <scp>II<\/scp>\n                    Trial"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5228-467X","authenticated-orcid":false,"given":"Benedikt","family":"Niedermaier","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Thoraxklinik Heidelberg University Hospital  Heidelberg Germany"},{"name":"Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL)  Heidelberg Germany"},{"name":"Division of Systems Biology of Signal Transduction German Cancer Research Center (DKFZ), DKFZ\u2010ZMBH Alliance  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4162-7881","authenticated-orcid":false,"given":"Tilmann","family":"Bochtler","sequence":"additional","affiliation":[{"name":"Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL)  Heidelberg Germany"},{"name":"Department of Medical Oncology Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University  Heidelberg Germany"},{"name":"Department of Thoracic Oncology, Thoraxklinik Heidelberg University Hospital  Heidelberg 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Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Allg\u00e4uer","sequence":"additional","affiliation":[{"name":"Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL)  Heidelberg Germany"},{"name":"Institute of Pathology, Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1001-103X","authenticated-orcid":false,"given":"Albrecht","family":"Stenzinger","sequence":"additional","affiliation":[{"name":"Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL)  Heidelberg Germany"},{"name":"Institute of Pathology, Heidelberg University Hospital  Heidelberg 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