{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:04:06Z","timestamp":1784887446626,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Neurosurgical resection of spinal metastases is an established treatment option for selected patients with advanced malignancies. However, high perioperative morbidity and mortality may further compromise outcomes in this vulnerable population, emphasizing the need to identify modifiable prognostic factors. Perioperative anemia is common and clinically relevant, yet its impact in this setting remains insufficiently studied. This retrospective, single\u2010center study included 279 patients who underwent surgical treatment for spinal metastases between 2013 and 2025. Patients were stratified into three groups based on perioperative hemoglobin levels. Multivariable logistic regression, Cox proportional hazards models, and Kaplan\u2013Meier analyses were used to assess associations between perioperative hemoglobin levels and postoperative complications, local recurrence, recurrence\u2010free survival, and mortality at 1\u2009month and 1\u2009year after surgery. Preoperative anemia was independently associated with an increased risk of hospital\u2010acquired complications (odds ratio [OR] 2.31, 95% confidence interval [CI] 1.35\u20133.97,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002), while higher hemoglobin levels showed a protective effect. No significant association was found between perioperative hemoglobin levels and surgical complications (OR 0.73, 95% CI 0.36\u20131.51,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.400). Postoperative hemoglobin levels and perioperative hemoglobin changes were not significantly associated with complications (OR 1.008, 95% CI 0.990\u20131.026,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.389) or mortality. One\u2010month and one\u2010year mortality rates were lowest in patients without anemia and highest in those with severe anemia. Our data demonstrate that early identification and optimization of preoperative anemia may reduce postoperative complications and potentially improve survival outcomes in patients undergoing surgery for spinal metastases.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70513","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T15:25:13Z","timestamp":1777303513000},"page":"1391-1400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Perioperative Anemia in Neurosurgical\u2010Oncological Treatment of Spinal Metastases"],"prefix":"10.1002","volume":"159","author":[{"given":"Marija","family":"Janjic","sequence":"first","affiliation":[{"name":"Department of Neurosurgery University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logman","family":"Khalafov","sequence":"additional","affiliation":[{"name":"Department of 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