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This study tried to understand the occurrence of CINV in patients receiving two different chemotherapy regimens. As part of the randomized controlled clinical trial SUCCESS C (NCT00847444), 1582 of the 3463 patients completed CINV diaries. Patients were randomized to receive either chemotherapy with FEC (5\u2010fluorouracil, epirubicin, cyclophosphamide followed by docetaxel) or TC (docetaxel, cyclophosphamide). CINV was evaluated hourly using a specially designed questionnaire. Endpoints of the study were complete response (no emesis) and total control (no nausea and no emesis) and were assessed with Kaplan\u2013Meier curves and Cox regression analyses over three chemotherapy cycles. Eight hundred fourteen patients received FEC and 768 received TC; patients and tumor characteristics were similar in both groups. Patients receiving FEC had significantly more nausea and vomiting, with the main difference in the first 12\u2009h. In the first cycle, the 0\u201312\u2010h nausea\/emesis\u2010free rates were 70%\/41% for FEC and 91\/76% for TC. By 24\u2009h after chemotherapy, the rates were 65%\/33% (FEC) and 85%\/60% (TC). The differences were similar in cycles 2 and 3. The detailed analysis of CINV in the study is unique and paves the way for modern CINV analysis of new therapeutics such as antibody\u2010drug conjugates.<\/jats:p>","DOI":"10.1002\/ijc.70528","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:30:36Z","timestamp":1777519836000},"page":"1990-2003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemotherapy\u2010Induced Nausea and Vomiting in Early Breast Cancer Patients Receiving Adjuvant Chemotherapy With Fluorouracil, Epirubicin, Cyclophosphamide Followed by Docetaxel Versus an Anthracycline\u2010Free Regimen With Docetaxel, Cyclophosphamide\u2014Results From a Randomized Clinical Trial"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6934-992X","authenticated-orcid":false,"given":"Manuel","family":"H\u00f6rner","sequence":"first","affiliation":[{"name":"Department of Gynecology and 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