{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:11:39Z","timestamp":1792606299070,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["D59D1600213000"],"award-info":[{"award-number":["D59D1600213000"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In Italy, the first women invited for HPV vaccination at 15\u201316\u2009years reached the age for cervical screening (25\u2009years) in 2018. The real\u2010world vaccination impact was evaluated. Women born in 1993\u20131996 invited for organised cervical screening in three Italian areas in 2018\u20132022 were eligible. After informed consent, they were tested for high\u2010risk HPV and genotyped. Positives, triaged by cytology, were immediately referred to colposcopy if ASCUS+ (irrespective of genotyping); otherwise, recalled for cytology after 3\u2009years. We estimated the relative (vaccinated with \u2265\u20092 doses vs. unvaccinated women) infection prevalence of three groups of genotypes: HPV16\/18, HPV31\/33\/45 and HPV 35, 39, 51, 52, 56, 58, 59, 66, 68 (\u2018non\u2010vaccine preventable\u2019) and the relative positive predictive value (PPV) for histology\u2010based CIN2+ detected at immediate colposcopy. Of 14,346 enrolled women, 34% had no vaccination, 66% \u2265\u20092 doses. The relative infection prevalence was 0.05 (0.03\u20130.10) for HPV16\/18 without non\u2010vaccine genotypes, 1.36 (1.23\u20131.50) for non\u2010vaccine genotypes without HPV16\/18 infections and 0.06 (0.03\u20130.12) for co\u2010infections by both groups. The relative PPV for CIN2+ was very high (4.09; 1.40\u201312.01) in vaccinated women co\u2010infected by HPV16\/18 and non\u2010vaccine types (4\/9 vs. 7\/84 cases) but reduced to zero in case of stand\u2010alone HPV16\/18 infections (0\/12 vs. 15\/117 cases). The CIN2+ relative detection in women infected only by non\u2010vaccine types was 1.57 (0.87\u20132.82). The increase in infections and high\u2010grade CIN from the pool of all non\u2010vaccine genotypes requires further research (including pooling of data) to be confirmed with longer follow\u2010up and on a larger study population.<\/jats:p>","DOI":"10.1002\/ijc.70536","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T15:00:31Z","timestamp":1777993231000},"page":"1686-1696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Population\u2010Based First Estimates of the Effect of\n                    <scp>HPV<\/scp>\n                    Vaccination in Three Italian Areas Covered by Organised Cervical Screening"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8965-4307","authenticated-orcid":false,"given":"Paola","family":"Armaroli","sequence":"first","affiliation":[{"name":"Unit of Cancer Epidemiology and Screening \u2010 Center for Cancer Prevention (CPO), City of Health and Science Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Zappa","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Clinical Governance Support Unit \u2010 Oncological Network, Prevention and Research Institute (ISPRO)  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9703-2460","authenticated-orcid":false,"given":"Paolo","family":"Giorgi Rossi","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Azienda Unit\u00e0 Sanitaria Locale\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca M.","family":"Carozzi","sequence":"additional","affiliation":[{"name":"Regional Laboratory of Cancer Prevention Unit \u2010 Oncological Network Prevention and Research Institute (ISPRO)  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-9531","authenticated-orcid":false,"given":"Raffaella","family":"Rizzolo","sequence":"additional","affiliation":[{"name":"Center for Cancer Epidemiology and Prevention (CPO)  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen B.","family":"Visioli","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Clinical Governance Support Unit \u2010 Oncological Network, Prevention and Research Institute (ISPRO)  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"De Marco","sequence":"additional","affiliation":[{"name":"Unit of Cancer Epidemiology \u2010 Center for Cancer Prevention (CPO), City of Health and Science Hospital  Turin Italy"},{"name":"Center for Cervical Screening \u2010 Center for Cancer Prevention (CPO) City of Health and Science Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Bisanzi","sequence":"additional","affiliation":[{"name":"Regional Laboratory of Cancer Prevention Unit \u2010 Oncological Network Prevention and Research Institute (ISPRO)  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarosa","family":"Del Mistro","sequence":"additional","affiliation":[{"name":"Immunology and Diagnostic Molecular Oncology Unit Veneto Oncology Institute IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Iossa","sequence":"additional","affiliation":[{"name":"Screening and Secondary Prevention Unit \u2010 Oncological Network, Prevention and Research Institute (ISPRO)  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina","family":"Bonelli","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Venturino","sequence":"additional","affiliation":[{"name":"Pathology Unit, ASL2 Liguria, San Paolo Hospital  Savona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9130-1620","authenticated-orcid":false,"given":"Elisa","family":"Camussi","sequence":"additional","affiliation":[{"name":"Unit of Cancer Epidemiology and Screening \u2010 Center for Cancer Prevention (CPO), City of Health and Science Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Viti","sequence":"additional","affiliation":[{"name":"Regional Laboratory of Cancer Prevention Unit \u2010 Oncological Network Prevention and Research Institute (ISPRO)  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3016-1131","authenticated-orcid":false,"given":"Guglielmo","family":"Ronco","sequence":"additional","affiliation":[{"name":"Center for Cancer Epidemiology and Prevention (CPO)  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917338"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2022.06.065"},{"key":"e_1_2_13_4_1","article-title":"Prevalence of Cervical Disease at Age 20 After Immunisation With Bivalent HPV Vaccine at Age 12\u201013 in Scotland: Retrospective Population Study","volume":"365","author":"Palmer T.","year":"2019","journal-title":"BMJ (Clinical Research 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