{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:04:06Z","timestamp":1784887446643,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    SMARCA4\u2010deficient thoracic tumor (SDTT) is a malignant tumor with a poor prognosis that often presents with distant metastases at the time of clinical diagnosis. Skeletal muscle metastasis is a rare subtype of metastasis patterns, and there are limited studies about SDTT metastasis in skeletal muscle. Herein, we retrospectively analyzed the data of stage IV patients diagnosed with SDTT from May 2009 to June 2024. The clinical and genomic data, imaging features, and treatment information were collected. As a result, the study included 145 patients with metastatic SDTT, 17 with skeletal muscle metastases, and 128 without. The rate of skeletal muscle metastasis in SDTTs was 11.7%. Multivariate Cox regression analysis showed that skeletal muscle metastases (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014, hazard ratio 95% confidence interval [HR 95% CI] [2.90, 1.25\u20136.75]) and first\u2010line chemoimmunotherapy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001, HR 95% CI [0.31, 0.17\u20130.56]) were independent prognostic variables. Furthermore, patients with skeletal muscle metastases had a significantly shorter median overall survival (OS) than those without (13.20 vs. 18.6\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021) in metastatic SDTTs. The mutation rate of\n                    <jats:italic>STK11<\/jats:italic>\n                    and\n                    <jats:italic>KRAS<\/jats:italic>\n                    was higher in the skeletal muscle metastasis group (62.50% vs. 15.52%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008; 50.00% vs. 8.62%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009). In conclusion, SDTTs exhibited a high rate of skeletal muscle metastases. Skeletal muscle metastases and first\u2010line chemoimmunotherapy were independent prognostic factors for OS in SDTTs.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70537","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:06:37Z","timestamp":1777957597000},"page":"1546-1555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skeletal Muscle Metastasis in Patients With\n                    <scp>SMARCA4<\/scp>\n                    \u2010Deficient Thoracic Tumors: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1054-323X","authenticated-orcid":false,"given":"Xueyuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Hospital of Shantou University Medical College  Shantou China"},{"name":"Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3470-843X","authenticated-orcid":false,"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silang","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2378-6056","authenticated-orcid":false,"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4685-3055","authenticated-orcid":false,"given":"Ting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Hospital of Shantou University Medical College  Shantou China"},{"name":"Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-7608","authenticated-orcid":false,"given":"Yuanyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sun Yatsen University Cancer Center  Guangzhou China"},{"name":"State Key Laboratory of Oncology in South China  Guangzhou China"},{"name":"Guangdong Provincial Clinical Research Center for Cancer  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.11.003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.11"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.108022"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-21-0433"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.3118"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6083"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.107471"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2024.107818"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.6809"},{"issue":"5","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jtho.2020.01.002","article-title":"Clinicopathologic Characteristics of BRG1\u2010Deficient NSCLC","volume":"15","author":"Dagogo\u2010Jack I.","year":"2020","journal-title":"Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-1825"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.762598"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19402-8"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-24-381"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402-017-2782-z"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.13069"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.19.00114"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-021-07099-4"},{"key":"e_1_2_12_20_1","article-title":"A Case Report and Literature Review of Skeletal Muscle Metastasis of Non\u2010Small Cell Lung Cancer","volume":"26","author":"Youn L.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_12_21_1","article-title":"A Rare Case of Non\u2010Small Cell Lung Cancer With Skeletal Metastasis to the Sartorius Muscle","volume":"16","author":"Faraz 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V.","year":"2021","journal-title":"Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02274-z"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2025.116153"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:24:09Z","timestamp":1784885049000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,4]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,9,15]]}},"alternative-id":["10.1002\/ijc.70537"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70537","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,4]]},"assertion":[{"value":"2025-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}