{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:06:45Z","timestamp":1787321205964,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Long\u2010term survival in metastatic colorectal cancer (mCRC) can be achieved by curative\u2010intent metastasectomy. Patients ineligible for upfront (primary) metastasectomy (PM) may become candidates for secondary metastasectomy (SM) following response to primary chemotherapy (PCT), still with curative intent. Most studies focus either on resectable or unresectable mCRC, limiting insights into differential subgroup benefits. Here, real\u2010world data offer a comprehensive evaluation of PM, SM, and PCT. We analyzed real\u2010world data from mCRC patients treated at the certified Comprehensive Cancer Center of the LMU Hospital (CCC Munich\n                    <jats:sup>LMU<\/jats:sup>\n                    ) from 2007 to 2021, following ESMO's guidance for real\u2010world evidence (GROW). Overall survival (OS) data were matched with the Bavarian Cancer Registry. OS was assessed using Kaplan\u2013Meier estimates and Cox regression analysis, adjusting for prognostic factors, including primary tumor sidedness and number of metastatic sites. Of 840 evaluable patients, 166 (20%) underwent PM, 520 (62%) received PCT, and 109 (13%) became eligible for SM after response to systemic treatment. OS was significantly longer for PM versus PCT (82.3 vs. 41.6\u2009months, HR\u2009=\u20090.47,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Multivariate analysis confirmed PM benefit across all subgroups, including high\u2010risk patients (e.g., right\u2010sided and multisite mCRC). OS was comparable between PM and SM (82.3 vs. 80.9\u2009months), whereas patients ineligible for local treatments had the worst OS (25\u2009months). Both PM and SM were associated with excellent OS, also for patients with high\u2010risk mCRC. Our findings underscore the importance of initial evaluation and continuous reassessment of resectability throughout the course of treatment against mCRC, as implemented at the CCC Munich\n                    <jats:sup>LMU<\/jats:sup>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/ijc.70540","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:30:42Z","timestamp":1778311842000},"page":"2025-2035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Relevance of Curative\u2010Intent Metastasectomy in Colorectal Cancer Patients: Real\u2010World Insights From a Certified Comprehensive Cancer Center in Germany"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4755-0179","authenticated-orcid":false,"given":"Julian W.","family":"Holch","sequence":"first","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Cancer Center (CCC Munich<sup>LMU<\/sup>) LMU University Hospital Munich  Munich Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Munich and German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Bavarian Cancer Research Center (BZKF)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0539-6087","authenticated-orcid":false,"given":"Jo\u2010Ann","family":"Eisenburger","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Cancer Center (CCC Munich<sup>LMU<\/sup>) LMU University Hospital Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Cancer Center (CCC Munich<sup>LMU<\/sup>) LMU University Hospital Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kammermeier\u2010Wehlau","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Cancer Center (CCC Munich<sup>LMU<\/sup>) LMU University Hospital Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Wiberg","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Cancer Center (CCC Munich<sup>LMU<\/sup>) LMU University Hospital Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Allmendinger","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Heidelberg University Hospital, Heidelberg University  Heidelberg Germany"},{"name":"National Center for Radiation Research in Oncology (NCRO) Heidelberg Institute for Radiation Oncology (HIRO)  Heidelberg Germany"},{"name":"National Center for Tumor Diseases (NCT) NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital  Heidelberg Germany"},{"name":"Department of Radiation Oncology, Heidelberg Ion\u2010Beam Therapy Center (HIT) Heidelberg University Hospital, Heidelberg University  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Cancer Center (CCC Munich<sup>LMU<\/sup>) LMU University Hospital Munich  Munich Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Munich and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Cancer Center (CCC Munich<sup>LMU<\/sup>) LMU University Hospital Munich  Munich Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Munich and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Benedikt","family":"Westphalen","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive Cancer Center (CCC Munich<sup>LMU<\/sup>) LMU University Hospital Munich  Munich Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Munich and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Krenmayr","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center (CCC Munich<sup>LMU<\/sup>) LMU University Hospital Munich  Munich Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Munich and German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Dorman","sequence":"additional","affiliation":[{"name":"Department of Medicine III University Hospital, LMU Munich  Munich Germany"},{"name":"Comprehensive 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