{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:08:43Z","timestamp":1788768523864,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24\u201045\u201010014"],"award-info":[{"award-number":["24\u201045\u201010014"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Non\u2010small cell lung cancer (NSCLC) patients with EGFR mutations usually receive continuous treatment with tyrosine kinase inhibitors (TKIs) until disease progression. We evaluated whether surgical excision of residual tumor masses offers a survival advantage when performed before progression on TKI therapy. We conducted a retrospective analysis of 230 patients with locally advanced or metastatic EGFR\u2010mutated NSCLC who were treated with first\u2010line EGFR TKI. Among these subjects, surgical intervention appeared technically feasible in 57 patients, 41 of whom underwent cytoreductive surgery while 16 were not operated for various reasons. Both surgically treated and nonsurgically treated patients received TKI until disease progression. The median duration of TKI treatment before surgery was 7.3\u2009months. There was no perioperative mortality, while 8\/41 (19.5%) patients experienced surgery\u2010related complications. The median progression\u2010free survival (PFS) and overall survival (OS) in the surgically treated group were 28.4\u2009months and 46.9\u2009months, respectively. These outcomes were significantly better than in patients with potentially resectable disease who did not undergo surgery (PFS: 15.4\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010; OS: 26.5\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.015), or in subjects not amenable to cytoreduction (PFS: 19.0\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006; OS: 31.7\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Mutation analysis of residual tumor tissues revealed emerging TKI\u2010resistant clones in 4 of 21 investigated patients. At the time of data cut\u2010off, 12\/41 (29%) surgically treated patients remained disease\u2010free. In conclusion, surgical removal of residual tumor masses in EGFR\u2010mutated NSCLC during response to TKI may confer a survival advantage.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70543","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:55:08Z","timestamp":1781229308000},"page":"2244-2261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Removal of Residual Tumor Masses in Patients Undergoing Targeted Therapy for\n                    <scp>EGFR<\/scp>\n                    \u2010Mutated Locally Advanced or Metastatic Lung Cancer"],"prefix":"10.1002","volume":"159","author":[{"given":"Fedor","family":"Moiseenko","sequence":"first","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"},{"name":"N.N. Petrov Institute of Oncology  St.\u2010Petersburg Russia"},{"name":"I.I. Mechnikov North\u2010Western Medical University  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniil","family":"Stroyakovskiy","sequence":"additional","affiliation":[{"name":"Moscow City Hospital No. 62  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniy","family":"Levchenko","sequence":"additional","affiliation":[{"name":"N.N. Petrov Institute of Oncology  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Fedyanin","sequence":"additional","affiliation":[{"name":"Moscow \u0421linical \u0421enter \u00abKommunarka\u00bb  Moscow Russia"},{"name":"N.N. Blokhin Cancer Center  Moscow Russia"},{"name":"N.I. Pirogov Center for Surgery  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albina","family":"Gabina","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"},{"name":"N.N. Petrov Institute of Oncology  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani","family":"Oganesian","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"},{"name":"I.I. Mechnikov North\u2010Western Medical University  St.\u2010Petersburg Russia"},{"name":"St.\u2010Petersburg Pediatric Medical University  St. Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Belukhin","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stepanova","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4013-181X","authenticated-orcid":false,"given":"Ekaterina","family":"Stepanova","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizaveta","family":"Artemyeva","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Myslik","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Volkov","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Bogdanov","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Shuginova","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill","family":"Kryukov","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Kheinshtein","sequence":"additional","affiliation":[{"name":"N.P Napalkov Cancer Center  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif","family":"Allakhverdiev","sequence":"additional","affiliation":[{"name":"Russian Academy for Continuous Medical Education  Moscow Russia"},{"name":"Russian Medical University  Moscow Russia"},{"name":"A.S. Loginov Clinical and Research Center  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Zaberegniy","sequence":"additional","affiliation":[{"name":"Moscow City Hospital No. 62  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Akhmadiyarova","sequence":"additional","affiliation":[{"name":"Moscow City Hospital No. 62  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Popov","sequence":"additional","affiliation":[{"name":"Moscow City Hospital No. 62  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiya","family":"Danilova","sequence":"additional","affiliation":[{"name":"Moscow City Hospital No. 62  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy","family":"Sehniaidze","sequence":"additional","affiliation":[{"name":"Moscow City Hospital No. 62  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Savelov","sequence":"additional","affiliation":[{"name":"Moscow City Hospital No. 62  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Levchenko","sequence":"additional","affiliation":[{"name":"N.N. Petrov Institute of Oncology  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniy","family":"Slugin","sequence":"additional","affiliation":[{"name":"N.N. Petrov Institute of Oncology  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Lopushanskaya","sequence":"additional","affiliation":[{"name":"N.N. Petrov Institute of Oncology  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Kuligina","sequence":"additional","affiliation":[{"name":"N.N. Petrov Institute of Oncology  St.\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Aleksakhina","sequence":"additional","affiliation":[{"name":"N.N. 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