{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:08:47Z","timestamp":1788768527975,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite therapeutic advancements, approximately 50% of advanced melanoma patients succumb to metastatic disease. Molecular tumor boards (MTB) aim to identify targetable molecular alterations to guide individualized treatment strategies. Yet, real\u2010world data on patient selection, referral timing, recommendation rates, implementation, and clinical impact remain limited. In this exploratory retrospective bicenter analysis, we evaluated 80 patients with advanced melanoma who presented at institutional MTBs of two comprehensive cancer centers. Clinical and molecular tumor data were analyzed using bioinformatic tools to characterize mutation profiles, treatment recommendations, and their real\u2010world implementation. Most patients (88.3%) had stage IV melanoma at the time of presentation and had received a median of three prior systemic treatment lines. Actionable treatment recommendations were formulated in 77.9% of eligible cases, yet only 33.7% of recommendations were implemented. Non\u2010implementation was most commonly attributable to early patient death or regulatory barriers. Importantly, when recommended therapies were applied, patients experienced significantly improved progression\u2010free survival (7.85 vs. 4.34\u2009months; PFS ratio 1.8) and overall survival (10.64 vs. 5.06\u2009months) compared with patients in whom recommended treatments were not implemented. Among patients with implemented MTB recommendations (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200926), the median intra\u2010patient PFS ratio was 1.68, and 14 of 26 patients (53.8%) achieved a PFS ratio \u2265\u20091.3. These findings indicate that MTBs frequently generate clinically actionable recommendations for metastatic melanoma, but late\u2010stage referral substantially limits their real\u2010world implementation. When applied, molecularly guided treatment strategies may confer meaningful clinical benefit, underscoring the importance of earlier integration of MTBs into melanoma care pathways.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70554","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:03:24Z","timestamp":1778911404000},"page":"2290-2299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3999-5902","authenticated-orcid":false,"given":"Glenn","family":"Geidel","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Fleur Hiege Center for Skin Cancer Research University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Lowinus","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Metzger","sequence":"additional","affiliation":[{"name":"Institute of Medical Bioinformatics and Systems Medicine, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Czurda","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Schipperges","sequence":"additional","affiliation":[{"name":"Institute of Medical Bioinformatics and Systems Medicine, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Paul","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"R\u00fcnger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Fleur Hiege Center for Skin Cancer Research University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"K\u00f6tt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Fleur Hiege Center for Skin Cancer Research University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Heidrich","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Fleur Hiege Center for Skin Cancer Research University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"Institute of Tumor Biology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Lehr","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Freiburg; and German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Comprehensive Cancer Center Freiburg, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Miething","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Werner","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK), Partner Site Freiburg; and German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Comprehensive Cancer Center Freiburg, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Institute for Surgical Pathology, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"La\u00dfmann","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK), Partner Site Freiburg; and German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Comprehensive Cancer Center Freiburg, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"Institute for Surgical Pathology, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justus","family":"Duyster","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Freiburg; and German Cancer Research Center (DKFZ)  Heidelberg Germany"},{"name":"Comprehensive Cancer Center Freiburg, Medical Center\u2014University of Freiburg, Faculty of Medicine University of Freiburg  Freiburg 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