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We conducted a case\u2010cohort study of ~30,000 site\u2010specific incident cancer cases and &gt;\u20098000 subcohort participants nested within the China Kadoorie Biobank. Baseline plasma was assayed for IgG antibodies against 47 antigens from 20 pathogens (16 viruses, 3 bacteria, 1 parasite) using an Automated Multiplex Serology assay. We described seroprevalence by age, sex, areas and lifestyle factors; estimated adjusted odd ratios for correlates of pathogen seropositivity in the subcohort using multivariable logistic regression and adjusted hazard ratios for overall and selected cancers using Prentice\u2010weighted Cox models. Among subcohort participants, seroprevalence for most pathogens varied and was significantly associated with sex, region and birth cohort. Participants were seropositive for a mean of ~10 pathogens. Compared with seronegative participants, those seropositive for seven pathogens had significantly higher overall cancer risk, particularly for HCV (HR\u2009=\u20092.18, 95% CI: 1.90\u20132.49), CMV (1.23, 1.08\u20131.40) and HSV\u20102 (1.14, 1.09\u20131.18) and HPV\u201016 oncogenes (e.g., E6: 1.57, 1.40\u20131.75). Lower risks were observed for HSV\u20101 (0.88, 0.81\u20130.95) and among those with fewer co\u2010infections. There were expected positive associations of liver cancer with HBV (2.29, 2.06\u20132.54) and HCV (7.05, 4.31\u201311.54) and of stomach cancer with\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>H. pylori<\/jats:italic>\n                    <\/jats:styled-content>\n                    (1.91, 1.68\u20132.17). In Chinese adults, multiple chronic infections were associated with risk of overall and certain selected cancers. Further research is warranted to investigate pathogen\u2010specific and co\u2010infection\u2010related risks of site\u2010specific cancers.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70555","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:50:46Z","timestamp":1779169846000},"page":"1282-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Burden and Correlates of Multiple Chronic Infections and Their Associations With Cancer Incidence in Chinese Adults: A Large Case\u2010Cohort Study"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-6588","authenticated-orcid":false,"given":"Ling","family":"Yang","sequence":"first","affiliation":[{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford  Oxford 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