{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:06:40Z","timestamp":1787321200390,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Colorectal cancer (CRC) incidence and mortality have increased significantly in the Asia\u2010Pacific region over the past three decades. Taiwan is not reported but presents one of the globally highest age\u2010standardized EOCRC incidence and mortality rates. This population\u2010based study in Taiwan from 1994 to 2018 examines changing CRC epidemiology among younger adults (aged 15\u201329 and 30\u201349\u2009years) and older adults (aged \u2265\u200950\u2009years). Age\u2010period\u2010cohort modeling (APC) and average annual percentage change (AAPC) analyses indicated that the elevated risk of age\u2010standardized EOCRC incidence and mortality was primarily driven by the aged 30\u201349\u2010year\u2010old cohort, whereas only modest increases were observed in adults aged \u2265\u200950\u2009years. Significant cohort effects were observed in the APC analysis, with annual increases of 3580 and 1000 per 100,000 in incidence and mortality, respectively, among the 30\u201349\u2010year\u2010old cohort, compared with increases of 2600 and 800 per 100,000, respectively, in the \u2265\u200950\u2010year\u2010old cohort. Furthermore, participants aged 15\u201329\u2009years were more frequently diagnosed at stages 3 and 4, resulting in a 7.8% lower survival rate compared with the 30\u201349\u2010year\u2010old cohort. The key risk factors unique to younger patients with CRC are summarized, highlighting the urgent need for tailored policy interventions.<\/jats:p>","DOI":"10.1002\/ijc.70560","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T04:55:32Z","timestamp":1779857732000},"page":"1928-1936","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population\u2010Based Study in Taiwan, 1994\u20132018"],"prefix":"10.1002","volume":"159","author":[{"given":"Yun\u2010Chen","family":"Tsai","sequence":"first","affiliation":[{"name":"School of Public Health Taipei Medicine University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Population Health Sciences, National Health Research Institutes  Miaoli Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010I","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shin Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4545-9697","authenticated-orcid":false,"given":"Hung\u2010Yi","family":"Chiou","sequence":"additional","affiliation":[{"name":"School of Public Health Taipei Medicine University  Taipei Taiwan"},{"name":"Institute of Population Health Sciences, National Health Research Institutes  Miaoli Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327736"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00600-4"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3399\/BJGPO.2020.0181"},{"key":"e_1_2_11_6_1","unstructured":"World Cancer Research Fund Internationalaccessed March 2023 https:\/\/www.wcrf.org\/cancer\u2010trends\/colorectal\u2010cancer\u2010statistics\/."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00432-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.07.055"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21772"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16162883"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-2886"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2022.100575"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2019.00021"},{"key":"e_1_2_11_15_1","first-page":"519","article-title":"The Risk Factors Affecting Survival in Colorectal Cancer in Taiwan","volume":"47","author":"Chao\u2010Hsien L.","year":"2018","journal-title":"Iranian Journal of Public Health"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.04.022"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.04056"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30147-5"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101174"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0562-9"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-63143-3"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47359-5"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-021-00510-x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09025-8"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-50077-7"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2080-8"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.03.10.23287127"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-024-01224-z"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-023-01162-w"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2022.100829"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030866"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01375-x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac215"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.5639"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.54753"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.29494"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.11.001"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2024.03.037"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2021.1950991"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092025"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-331914"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-1467"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16233928"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2024.101425"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104574"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16112004"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-54972-3"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.102857"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323450"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:09:00Z","timestamp":1787317740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10,15]]}},"alternative-id":["10.1002\/ijc.70560"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70560","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2025-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}