{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:21:40Z","timestamp":1788265300565,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Recent evidence suggests that carriers of a pathogenic germline variant (PGV) in\n BRCA1<\/jats:italic>\n or\n BRCA2<\/jats:italic>\n may have an increased risk of gastric cancer (GC). However, the specific mechanisms underlying gastric carcinogenesis remain uncertain. Strikingly, recent data have demonstrated that Japanese\n BRCA1<\/jats:italic>\n and\n BRCA2<\/jats:italic>\n PGV carriers with\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n (\n Hp<\/jats:italic>\n ) exposure have a substantially increased risk of GC compared to non\u2010carriers with\n Hp<\/jats:italic>\n exposure, indicating that\n Hp<\/jats:italic>\n may be an important risk factor for\n BRCA1<\/jats:italic>\n and\n BRCA2<\/jats:italic>\n \u2010associated GC. However, rates of\n Hp<\/jats:italic>\n exposure amongst broader\n BRCA1<\/jats:italic>\n and\n BRCA2<\/jats:italic>\n PGV cohorts are currently unknown. In this study, 1034 United States\u2010based\n BRCA1<\/jats:italic>\n and\n BRCA2<\/jats:italic>\n PGV carriers along with 293\n PALB2<\/jats:italic>\n ,\n ATM<\/jats:italic>\n , and\n TP53<\/jats:italic>\n PGV carriers were assessed for\n Hp<\/jats:italic>\n exposure by assessing\n Hp<\/jats:italic>\n IgG positivity in plasma samples. The combined rate of\n Hp<\/jats:italic>\n exposure in\n BRCA1<\/jats:italic>\n and\n BRCA2<\/jats:italic>\n carriers was 17.4%. Individually,\n BRCA1<\/jats:italic>\n and\n BRCA2<\/jats:italic>\n carriers had an exposure rate of 16.4% and 18.2%, respectively. Similarly,\n PALB2<\/jats:italic>\n ,\n ATM<\/jats:italic>\n , and\n TP53<\/jats:italic>\n carriers had a combined\n Hp<\/jats:italic>\n exposure rate of 18.4%. Among all groups, non\u2010White race was significantly associated with\n Hp<\/jats:italic>\n exposure. Approximately 1 in 6\n BRCA1<\/jats:italic>\n ,\n BRCA2<\/jats:italic>\n , and other DNA repair\u2010related gene PGV carriers had\n Hp<\/jats:italic>\n exposure. Future studies are needed to determine the impact of\n Hp<\/jats:italic>\n exposure versus active\n Hp<\/jats:italic>\n infection on GC risk in these high\u2010risk individuals.\n <\/jats:p>","DOI":"10.1002\/ijc.70572","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:14:06Z","timestamp":1781324046000},"page":"1663-1668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of\n \n Helicobacter pylori<\/i>\n <\/scp>\n Exposure and Risk Factors Among\n \n BRCA1<\/i>\n <\/scp>\n and\n \n BRCA2<\/i>\n <\/scp>\n Carriers"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2125-2145","authenticated-orcid":false,"given":"Kole H.","family":"Buckley","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Dinh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Hausler","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Gala","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia R.","family":"Spiegel","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosella","family":"Delgado","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Clay","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Brower","sequence":"additional","affiliation":[{"name":"Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Domchek","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara N.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8186-9119","authenticated-orcid":false,"given":"Bryson W.","family":"Katona","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"},{"name":"Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania 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