{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:06:45Z","timestamp":1787321205082,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006389","name":"Universit\u00e9 de Gen\u00e8ve","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006389","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013362","name":"Swiss Cancer Research Foundation","doi-asserted-by":"publisher","award":["KFS 5312\u201002\u20102021"],"award-info":[{"award-number":["KFS 5312\u201002\u20102021"]}],"id":[{"id":"10.13039\/501100013362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The World Health Organization (WHO) recommends HPV\u2010DNA testing as the primary screening method for cervical cancer in low\u2010 and middle\u2010income countries (LMICs), yet guidance on how to triage HPV\u2010positive women remains limited. The 2021 WHO guidelines for LMICs do not incorporate extended HPV genotyping, despite its potential to improve risk stratification and support scalable management strategies. This study evaluated screening strategies based on locally available resources for management of HPV\u2010positive women. We retrospectively analyzed data from the 3T study (Test, Triage, and Treat), conducted between 2018 and 2022, which included HPV self\u2010sampling and VIA triage among women aged 30\u201349\u2009years. For all HPV\u2010positive participants, HPV testing (stratified into five genotype\u2010based risk groups), cytology, VIA, cervical\u2010biopsy, and endocervical\u2010brush histopathology were available. Thirty\u2010five screening and triage strategies integrating HPV extended genotyping alone or in combination with VIA or cytology were assessed using CIN3+ risk as a guiding principle. Among 868 HPV\u2010positive women, 9% had CIN3+ lesions. HPV types 31\/33\/35\/52\/58 were most prevalent, whereas HPV16 and HPV18\/45 carried the highest CIN3+ risks. Strategies combining extended genotyping with cytology demonstrated the best balance of sensitivity and specificity. In settings without access to cytology or VIA, direct treatment of the eight highest\u2010risk HPV types, 16\/18\/45\/31\/33\/35\/52\/58, showed the best balance between sensitivity and specificity. When cytology or VIA was available, immediate treatment for HPV16 and reflex triage, cytology (treating\u2009\u2265\u2009ASCUS lesions), or VIA for HPV18\/45\/31\/33\/35\/52\/58 showed the best trade\u2010off. The proposed screening strategies enable risk\u2010adapted triage and guide management decisions based on available resources.<\/jats:p>","DOI":"10.1002\/ijc.70573","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:10:07Z","timestamp":1781781007000},"page":"1949-1961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Resource\u2010Adapted Triage Strategies for Women Testing\n                    <scp>HPV<\/scp>\n                    Positive With Self\u2010Collected Vaginal Samples in Cameroon"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0060-4605","authenticated-orcid":false,"given":"Micol","family":"Murtas","sequence":"first","affiliation":[{"name":"Gynecologic Division, Department of Pediatrics, Gynecology, and Obstetrics University Hospitals Geneva, University of Geneva  Geneva 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Geneva, University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-5908","authenticated-orcid":false,"given":"Marc","family":"Arbyn","sequence":"additional","affiliation":[{"name":"Unit of Cancer Epidemiology Belgian Cancer Centre  Brussels Belgium"},{"name":"Department of Human Structure and Repair, Faculty of Medicine and Health Sciences University of Ghent  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles W.","family":"Tankeu Happi","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Dschang Regional Annex Hospital  Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Abatsong","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Dschang Regional Annex Hospital  Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois Marcel Ndam","family":"Nsangou","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics Dschang Regional Annex Hospital  Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Tille","sequence":"additional","affiliation":[{"name":"Division of Clinical Pathology Diagnostic Department Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essia","family":"Saiji","sequence":"additional","affiliation":[{"name":"Division of Clinical Pathology Diagnostic Department Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Kenfack","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine and Pharmaceutical Sciences University of Dschang  Dschang Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Petignat","sequence":"additional","affiliation":[{"name":"Gynecologic Division, Department of Pediatrics, Gynecology, and Obstetrics University Hospitals Geneva, University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.11.006"},{"key":"e_1_2_13_3_1","unstructured":"Organisation Mondiale de la Sant\u00e9 (OMS) \u201cTarget Product Profiles for Human Papillomavirus Screening Tests to Detect Cervical Pre\u2010Cancer and Cancer [En Ligne] \u201d 2024 https:\/\/iris.who.int\/bitstream\/handle\/10665\/379099\/9789240100275\u2010eng.pdf?sequence=1."},{"key":"e_1_2_13_4_1","unstructured":"\u201cNew Recommendations for Screening and Treatment to Prevent Cervical Cancer [Internet] \u201d 2025 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