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It was found that the bioactive Ti could be initiated with a photodynamic effect by X\u2010ray used for bone tumor treatment, which could produce a large amount of reactive oxygen species (ROS). This effect could affect the ROS balance of bone tumor cells, cause oxidative stress in the bone tumor cells, and promote apoptosis of bone tumor cells. In the animal test, it was found that the photodynamic therapy (PDT) of the bioactive Ti metal could inhibit bone tumor growth, which implies that the bioactive Ti metal could be endowed with anti\u2010tumor properties during the X\u2010ray therapeutic process. It is hopeful to get Ti metal with synergistic bio\u2010functions with both bioactivity and anti\u2010tumor properties by surface modification.<\/jats:p>","DOI":"10.1002\/ijc.70577","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:02:38Z","timestamp":1781179358000},"page":"2498-2511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photodynamic Effect of Bioactive Titanium Metal Initiated by X\u2010Ray and Its Potential Application for Bone Tumor Treatment"],"prefix":"10.1002","volume":"159","author":[{"given":"Jun","family":"Chen","sequence":"first","affiliation":[{"name":"Engineering Research Center in Biomaterials, Sichuan University  Chengdu China"},{"name":"School of Biomedical Engineering, Sichuan University  Chengdu China"},{"name":"National Engineering Research Center for Biomaterials  Chengdu 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