{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:21:56Z","timestamp":1793247716317,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Icaritin's efficacy was evaluated for unresectable advanced hepatocellular carcinoma (HCC), a major global burden with limited advanced\u2010stage treatment options. A multicenter retrospective real\u2010world study (May 2022\u2013May 2024) included 163 patients with unresectable advanced HCC. Treatments were Icaritin monotherapy, Icaritin + anti\u2010VEGF, or Icaritin + PD\u20101 inhibitors + anti\u2010VEGF. Primary endpoints were progression\u2010free survival (PFS) and overall survival (OS); secondary endpoints were objective response rate (ORR) and disease control rate (DCR). Subgroup analyses assessed alpha\u2010fetoprotein (AFP) impact. In first\u2010line treatment, Icaritin monotherapy achieved an ORR of 26.32%. Combining Icaritin with PD\u20101 inhibitors and anti\u2010VEGF agents increased ORR to 38.30%. Median PFS was 4.27\u2009months for monotherapy; second\u2010line median OS for Icaritin monotherapy reached 19.91\u2009months. Patients with AFP\u2009&lt;\u2009400\u2009ng\/mL generally showed numerically better PFS in first\u2010line regimens compared to those with AFP \u2265\u2009400\u2009ng\/mL. Patients with high AFP treated with Icaritin + PD\u20101 inhibitors demonstrated a promising response. Icaritin shows promising efficacy in unresectable HCC, particularly in patients with lower AFP levels. The findings support personalized treatment strategies and warrant further research to optimize outcomes and elucidate Icaritin's mechanisms.<\/jats:p>","DOI":"10.1002\/ijc.70590","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:16:09Z","timestamp":1781165769000},"page":"2525-2539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010World Evidence on the Efficacy of Icaritin for Unresectable Advanced Hepatocellular Carcinoma: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"159","author":[{"given":"Dinghu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Interventional Therapy Zhejiang Cancer Hospital  Hangzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinfen","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Shulan (Hangzhou) 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