{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:06:35Z","timestamp":1787321195162,"version":"build-2736575974"},"reference-count":88,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late\u2010stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high\u2010grade precursors before clinical symptoms arise in patients at elevated risk of PDAC development. Classical imaging\u2010based surveillance strategies, aligned with current guidelines, form the foundation of screening high\u2010risk individuals, while organ\u2010specific fluid analyses\u2014such as cyst fluid and pancreatic juice\u2014offer promising complementary tools with enhanced specificity. Recent advances in radiomics, liquid biopsy, microbiome, and multi\u2010omics profiling are expanding the frontier of early detection. Despite advances, significant challenges persist. Precursor lesions are difficult to non\u2010invasively diagnose; are not radiologically or endosonographically visible, or cannot be definitively graded prior to resection. Though biomarkers show promise for early detection, they present unique challenges: early\u2010stage neoplasias release low levels of many biomarkers and thresholds for these biomarkers that define malignant transformation\u2014and thus guide surgical intervention\u2014remain poorly established. Multi\u2010institutional initiatives like the Pancreatic Cancer Early Detection consortium (PRECEDE) are critical to bridging discovery and clinical translation. Our international cohort study of high\u2010risk individuals was designed to discover and validate diagnostic biomarkers according to the PROBE study design. Continued collaboration, technological integration, and patient\u2010centered approaches are essential to transform early detection research into tangible survival benefits for those at risk of PDAC.<\/jats:p>","DOI":"10.1002\/ijc.70592","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:42:21Z","timestamp":1781584941000},"page":"1873-1883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic Cancer Early Detection Biomarkers for High\u2010Risk Individuals: Insights From the\n                    <scp>PRECEDE<\/scp>\n                    Consortium"],"prefix":"10.1002","volume":"159","author":[{"given":"Christine","family":"Worthington","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, College of Medicine University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Raitses\u2010Gurevich","sequence":"additional","affiliation":[{"name":"The Jusidman Cancer Center, Chaim Sheba Medical Center Tel HaShomer Hospital  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Innamorati","sequence":"additional","affiliation":[{"name":"Laboratory of Translational Surgery, Department of Surgery, Dentistry, Maternity and Infant University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil A.","family":"Hart","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, College of Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Wilkie","sequence":"additional","affiliation":[{"name":"Pharmacology Department UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Tau","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Chaim Sheba Medical Center Tel HaShomer Hospital, Tel Aviv University  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Brin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Chaim Sheba Medical Center Tel HaShomer Hospital, Tel Aviv University  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Yablecovitch","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, Chaim Sheba Medical Center Tel HaShomer Hospital, Tel Aviv University  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Laish","sequence":"additional","affiliation":[{"name":"Gastroenterology Institute, Chaim Sheba Medical Center Tel HaShomer Hospital, Tel Aviv University  Ramat Gan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dove","family":"Keith","sequence":"additional","affiliation":[{"name":"Brenden\u2010Colson Center for Pancreatic Care Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Giles","sequence":"additional","affiliation":[{"name":"Helen Diller Family Comprehensive Cancer Center University of California San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4726-9264","authenticated-orcid":false,"given":"Jennifer B.","family":"Permuth","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology, Department of Cancer Epidemiology Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane M.","family":"Simeone","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California San Diego Health, Moores Cancer Center  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Zogopoulos","sequence":"additional","affiliation":[{"name":"Department of Surgery, Department of Oncology McGill University and the Research Institute of the McGill University Health Centre  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall E.","family":"Brand","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Graff","sequence":"additional","affiliation":[{"name":"PRECEDE Data Coordinating Center Arbor Research Collaborative for Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9360-4716","authenticated-orcid":false,"given":"Julie","family":"Earl","sequence":"additional","affiliation":[{"name":"Biomarkers and Personalized Approach to Cancer (BIOPAC) Group Ramon y Cajal Health Research Institute, (IRYCIS)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PRECEDE Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.10.007"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10232"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.09.024"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.259"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.218"},{"key":"e_1_2_17_9_1","first-page":"144","article-title":"Diabetes Type 2 and Pancreatic Cancer: A History Unfolding","volume":"17","author":"Souza A.","year":"2016","journal-title":"Journal of the Pancreas: JOP"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.7097"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319352"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2021.12.001"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.1930"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn326"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.14.1054"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-0240"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-0237"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.08.036"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.11.052"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.10.036"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217450"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.05.007"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy090"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000002335"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000777"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000002027"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17917-8"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11122171"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2022.1035"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12204"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21883"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24277"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65720-8"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30974-0"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02332-5"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704961114"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.03.016"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.02.011"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-022-00088-6"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2400297"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-03960-8"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11219"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07359-3"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-0013"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1252"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6658"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000468"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2025.08.034"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000473"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215051"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.03.002"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70144"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adq3110"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(25)00056-1"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312432"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.07.047"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005904"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.09.028"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.297"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.04.1342"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318860"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i47.8345"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312580"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324755"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34287"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2024.108171"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.01.074"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-94183-y"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00287"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.1148\/rycan.2021210010"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.06.066"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02640-w"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-024-00381-4"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2025.05.011"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18820"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-025-00698-0"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53041-4"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300784"},{"key":"e_1_2_17_79_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.4_suppl.691"},{"key":"e_1_2_17_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46215-w"},{"key":"e_1_2_17_81_1","article-title":"Monitoring Physical Impact and Recovery of Pancreatic Cancer Treatment Using Consumer Wearable Health Data: A Case Report","volume":"9","author":"Schans C. P.","year":"2023","journal-title":"DIGITAL HEALTH"},{"key":"e_1_2_17_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.03.038"},{"key":"e_1_2_17_83_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.039"},{"key":"e_1_2_17_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40024-3"},{"key":"e_1_2_17_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlb.2025.100301"},{"key":"e_1_2_17_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2024.10.012"},{"key":"e_1_2_17_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2024.100824"},{"key":"e_1_2_17_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-025-01793-4"},{"key":"e_1_2_17_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-025-00750-w"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70592","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70592","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:08:57Z","timestamp":1787317737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":88,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10,15]]}},"alternative-id":["10.1002\/ijc.70592"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70592","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"assertion":[{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}