{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:11:21Z","timestamp":1790079081368,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF20OC0064537"],"award-info":[{"award-number":["NNF20OC0064537"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R379\u2010A22511"],"award-info":[{"award-number":["R379\u2010A22511"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Population\u2010based evidence on cancer survival in individuals with neurofibromatosis 1 (NF1) remains limited. We compared survival following a first neoplasm in individuals with NF1 to that of the general Danish population and stratified on age, sex, and potential survival\u2010related factors, including cancer stage and comorbidity. Using the Danish Cancer Registry, we identified 428 individuals with NF1 and 392,885 without NF1, all diagnosed with a first neoplasm (1977\u20132022). We estimated survival using Kaplan\u2013Meier methods, assessed neoplastic and nonneoplastic mortality, and evaluated prior inpatient disease burden in adults (aged 20\u201369\u2009years) based on hospital diagnoses 10\u2009years to 6\u2009months before neoplasm diagnosis. Among children (aged 1\u201319\u2009years), NF1 was overall associated with better 5\u2010year survival (NF1: 87.3% [81.1%\u201393.5%], non\u2010NF1: 78.7% [77.9%\u201379.6%]), due to better survival following central nervous system (CNS) neoplasms. In adults, 5\u2010year survival was lower in NF1 compared to the general population (57.0% [51.3%\u201362.6%] vs. 69.2% [69.0%\u201369.3%]). NF1 adults more often presented with stage IV breast (17.2% vs. 6.3%) and gastrointestinal cancers (52.5% vs. 37.7%). Among adults with no prior inpatient diagnoses, 5\u2010year survival was poorer in NF1 (60.1% [51.3%\u201368.9%] vs. 72.1% [71.9%\u201372.3%]). Five\u2010year neoplastic mortality was higher in NF1 adults (39.4% [33.8%\u201345.0%] vs. 27.7% [27.6%\u201327.9%]). In conclusion, individuals with NF1, particularly adults, have poorer cancer survival than the general population. Differences in cancer type and stage at diagnosis contribute but do not fully explain the excess mortality, indicating that factors beyond general health status may play a role.<\/jats:p>","DOI":"10.1002\/ijc.70608","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T11:13:34Z","timestamp":1781954014000},"page":"2408-2420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival Following Neoplastic Disease in Individuals With Neurofibromatosis 1\u2014A National Danish Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1840-7768","authenticated-orcid":false,"given":"Mia Aagaard","family":"Doherty","sequence":"first","affiliation":[{"name":"Childhood Cancer Research Group, Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine","family":"Grell","sequence":"additional","affiliation":[{"name":"Statistics and Data Analysis, Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Hove","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Centre for Rare Diseases Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette M.","family":"Handrup","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Centre for Rare Diseases Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Centre for Rare Diseases Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Kr\u00f8yer","sequence":"additional","affiliation":[{"name":"Childhood Cancer Research Group, Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas T.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Childhood Cancer Research Group, Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-6798","authenticated-orcid":false,"given":"Henrik","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Haematology Research Group, Danish Cancer Institute  Copenhagen Denmark"},{"name":"Department of Hematology Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Copenhagen University  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Mulvihill","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Oklahoma  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wohlfahrt","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology and Surveillance, Danish Cancer Institute  Copenhagen Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hasle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie","family":"Ejerskov","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Centre for Rare Diseases Aarhus University Hospital  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