{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:03:02Z","timestamp":1791201782375,"version":"4.2.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Treatment of sarcoma includes high\u2010dose anthracyclines, which can cause cardiotoxicity. This study assesses the correlation of cardiac biomarkers and echocardiographic parameters on asymptomatic cardiotoxicity in sarcoma patients treated with anthracyclines. Consecutive patients diagnosed with sarcoma and treated with anthracyclines were included in this retrospective cohort study using registry data. Echocardiography was performed before start of anthracycline chemotherapy (baseline), after completing treatment (short\u2010term follow\u2010up), and 6\u201312\u2009months after termination of treatment (long\u2010term follow\u2010up). The primary endpoint was the occurrence of asymptomatic cardiotoxicity at short\u2010term follow\u2010up. We included 44 patients (29.6% female) with a median age of 28.9 [22.2\u201338.7] years. Baseline left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) decreased significantly from 58.4%\u2009\u00b1\u20095.0% to 54.2%\u2009\u00b1\u20099.3% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.013) and \u221219.1%\u2009\u00b1\u20092.2% to \u221217.2%\u2009\u00b1\u20093.5% at short\u2010term follow\u2010up (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002), respectively. After Cycle 1, 86.5% of the patients showed NT\u2010proBNP \u2265\u2009125\u2009ng\/L compared to 3.9% at baseline (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and after completion of therapy, 65.5% had elevated cardiac Troponin T (cTnT) \u2265\u200914\u2009ng\/L compared to 11.5% at baseline (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003). Asymptomatic cardiotoxicity was observed in 30 patients (68.2%). Mean follow\u2010up was 2.4 [1.5\u20132.9] years. cTnT \u2265\u200914\u2009ng\/L after Cycle 4 was associated with cardiotoxicity (HR: 3.75 [1.28\u201311.0],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016), and NT\u2010proBNP per 100\u2009units increase after Cycle 1 was associated with an increased risk of mortality (HR: 1.36 [1.004\u20131.85],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.047). Sarcoma patients treated with high\u2010dose anthracyclines are at increased risk of developing cardiac dysfunction as assessed by LVEF and GLS. cTnT and NT\u2010proBNP levels increase significantly during treatment and can be valuable markers to improve the risk stratification of patients treated with high\u2010dose anthracyclines.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70620","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:20:05Z","timestamp":1782876005000},"page":"2755-2765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymptomatic Cardiotoxicity After High\u2010Dose Anthracycline Treatment in Sarcoma Patients Assessed by Biomarkers and Echocardiography"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-8620","authenticated-orcid":false,"given":"Elissa A. S.","family":"Polomski","sequence":"first","affiliation":[{"name":"Department of Cardiology, Heart Lung Center Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Speetjens","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Wouter","family":"Jukema","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center Leiden University Medical Center  Leiden the Netherlands"},{"name":"Netherlands Heart Institute  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius C.","family":"Heemelaar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel A. J.","family":"van de Sande","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Gelderblom","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Louisa","family":"Antoni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Lung Center Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Institute NC \u201cSEER Cancer Stat Facts: Bone and Joint Cancer \u201d(National Cancer Institute Bethesda MD) https:\/\/seer.cancer.gov\/statfacts\/html\/bones.html."},{"key":"e_1_2_13_3_1","volume-title":"Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29\u2009Years of Age, Including SEER Incidence and Survival: 1975\u20132000","author":"Bleyer A. O. L. 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