{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:03:28Z","timestamp":1791201808809,"version":"4.2.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The recommended adjuvant chemotherapy (adj\u2010ChT) regimen for resected biliary tract cancers (BTC) is capecitabine (Cape); yet, the recommendation is based on limited evidence. Although varied adj\u2010ChTs have been employed in practice, robust real\u2010world data is scarce. We conducted a national, multicenter, hospital\u2010based registry study to evaluate adj\u2010ChTs in resected BTCs. Patients who received adj\u2010ChT (\u00b1 radiotherapy) between 2010 and 2024 were included. Recurrence\u2010free (RFS) and overall survival (OS) were analyzed by adjusted Cox\u2010regression and propensity score\u2010based inverse\u2010probability\u2010of\u2010treatment\u2010weighting (IPTW), addressing selection bias. Among 617 patients from 44 centers, 513 were eligible. The most frequent adj\u2010ChTs were Cape (35.5% [\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009182]), gemcitabine\u2013cisplatin (Gem\u2010Cis; 22.4% [\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009115]), gemcitabine\u2013capecitabine (Gem\u2010Cape; 20.1% [\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009103]), and gemcitabine (Gem; 10.7% [\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200955]). Median RFS and OS with Cape were 19.7 (95% Confidence Interval [95% CI]: 14.2\u201341.1) and 41.9\u2009months (95% CI: 25.9\u201369.2). In adjusted\/controlled comparisons with Cape, no differences in RFS or OS were observed with Gem\u2010Cis (RFS: Hazard Ratio [HR] 1.13 [95% CI: 0.77\u20131.66]; OS: HR: 1.03 [95% CI: 0.66\u20131.61]), Gem\u2010Cape (RFS: HR 0.97 [95% CI: 0.68\u20131.38]; OS: HR: 0.81 [95% CI: 0.52\u20131.24]), or Gem (RFS: HR 1.00 [95% CI: 0.63\u20131.59]; OS: HR: 0.93 [95% CI: 0.55\u20131.57]). Similarly, IPTW analyses showed no difference in RFS and OS. Radiotherapy appeared to be associated with improved survival. Performance status, T\u2010stage, lymph\u2010node positivity, and R1\u2010resection were independently associated with RFS and OS. In conclusion, this real\u2010world study did not identify a regimen superior to Cape. Given the modest benefit of adj\u2010ChTs, novel approaches, including neoadjuvant and targeted\/immunotherapy strategies, are needed.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70623","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T18:25:51Z","timestamp":1782757551000},"page":"2766-2777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjuvant Chemotherapy Regimens in Resected Biliary Tract Cancers: National, Comparative, Observational Study (\n                    <scp>TOG<\/scp>\n                    \/\n                    <scp>GI<\/scp>\n                    \u2010\n                    <scp>SAFRADJU<\/scp>\n                    \u20102501)"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7531-7817","authenticated-orcid":false,"given":"Erman","family":"Akkus","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Ankara University Faculty of Medicine  Ankara T\u00fcrkiye"},{"name":"Cancer Research Institute Ankara University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-3161","authenticated-orcid":false,"given":"Mehmet","family":"Kayaalp","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ankara University Faculty of Medicine  Ankara T\u00fcrkiye"},{"name":"Cancer Research Institute Ankara University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fczeyyen Asl\u0131","family":"Erg\u00f6zo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Cukurova University Faculty of Medicine  Adana T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilg\u0131n","family":"Ko\u00e7 Ku\u015f","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hacettepe University Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do\u011fan","family":"Bayram","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Ankara Bilkent City Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilge\u015fah","family":"K\u0131l\u0131\u00e7ta\u015f","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Necmettin Erbakan University Faculty of Medicine  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Ayvaz G\u00fcneyin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Atat\u00fcrk University Faculty of Medicine  Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0937-0468","authenticated-orcid":false,"given":"Ali","family":"Kalem","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Gaziantep University Faculty of Medicine  Gaziantep T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haydar","family":"Temizy\u00fcrek","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Afyonkarahisar University of Health Sciences  Afyon T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Mutlu","family":"\u00c7atl\u0131","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Antalya Training and Research Hospital  Antalya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Sinan","family":"Akarca","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Dokuz Eyl\u00fcl University Faculty of Medicine  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4587-0726","authenticated-orcid":false,"given":"Maral 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