{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:58:34Z","timestamp":1785560314381,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173616"],"award-info":[{"award-number":["82173616"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The association between sodium\u2010glucose cotransporter\u20102 inhibitors (SGLT\u20102i) and cancer risk in type 2 diabetes mellitus (T2DM) patients remains controversial. This study aimed to investigate whether SGLT\u20102i use is associated with a reduced risk of overall or site\u2010specific cancer. Using the Shenzhen Public Health Data Platform, we emulated a target trial with an active\u2010comparator, new\u2010user design. Dipeptidyl peptidase\u20104 inhibitors (DPP\u20104i) and glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RA) were used as reference medications. Hazard ratios (HRs) and 95% confidence intervals (CIs) were assessed using overlapping weighting\u2010based Cox proportional hazards models. The cohort included 134,481 patients when using DPP\u20104i as comparator. During a median follow\u2010up of 1.8\u2009years, 1848 (2.2%) and 1557 (3.0%) cancer cases were identified among SGLT\u20102i and DPP\u20104i users. After adjusting for confounders, SGLT\u20102i was associated with a lower risk of overall cancer compared with DPP\u20104i (HR: 0.91; 95% CI: 0.85\u20130.98). A negative association was observed for site\u2010specific cancers, including lung (HR: 0.84; 95% CI: 0.72\u20130.98) and thyroid cancer (HR: 0.76; 95% CI: 0.61\u20130.96). In the comparison between SGLT\u20102i and GLP\u20101RA, 3371 (2.58%) cancer cases occurred. After adjustment, no significant difference in overall cancer risk was observed between SGLT\u20102i and GLP\u20101RA users (HR: 1.03; 95% CI: 0.85\u20131.25). SGLT\u20102i was associated with a reduced risk of lung and thyroid cancers compared with DPP\u20104i, while no statistically significant difference was observed relative to GLP\u20101RA. These findings provide supportive evidence for the safety of SGLT\u20102i regarding carcinogenic risk and suggest its potential role in cancer prevention strategies among T2DM patients.<\/jats:p>","DOI":"10.1002\/ijc.70642","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:20:08Z","timestamp":1785558008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sodium\u2010Glucose Cotransporter 2 Inhibitors and Cancer Risk in Patients With Type 2 Diabetes Mellitus: An Active Comparator, New\u2010User Cohort Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8880-8130","authenticated-orcid":false,"given":"Yuhao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University, Key Laboratory of Epidemiology of Major Diseases, Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huatang","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering Tsinghua University  Beijing China"},{"name":"Shenzhen Health Development Research and Data Management Center  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Du","sequence":"additional","affiliation":[{"name":"Shenzhen Health Development Research and Data Management Center  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Wu","sequence":"additional","affiliation":[{"name":"Shenzhen Health Development Research and Data Management Center  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiatong","family":"Ke","sequence":"additional","affiliation":[{"name":"Shenzhen Health Development Research and Data Management Center  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peifen","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Health Development Research and Data Management Center  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrine Glucose &amp; Lipids Metabolism and Brain Aging, Ministry of Education Shandong First Medical University  Jinan Shandong China"},{"name":"Department of Endocrinology Central Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Epidemiology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University, Key Laboratory of Epidemiology of Major Diseases, Ministry of Education  Beijing China"},{"name":"Institute for Artificial Intelligence Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13045-024-01640-8","article-title":"Global Burden of Cancer and Associated Risk Factors in 204 Countries and Territories, 1980\u20132021: A Systematic Analysis for the GBD 2021","volume":"17","author":"Wu Z.","year":"2024","journal-title":"Journal of Hematology & 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