{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:09:57Z","timestamp":1790078997689,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173104"],"award-info":[{"award-number":["82173104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871233"],"award-info":[{"award-number":["81871233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2026,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Early\u2010onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before the age of 50\u2009years, is increasing worldwide, with a similar trend emerging in China. However, the clinicopathological and mismatch repair features of EOCRC in Chinese patients remain insufficiently characterized. We retrospectively reviewed 23,414 colorectal neoplasia cases diagnosed at West China Hospital between November 2008 and June 2023. Among these, 4,159 colorectal cancer cases with complete immunohistochemical assessment of MLH1, PMS2, MSH2, and MSH6 were included in the primary analysis. Clinicopathological characteristics and mismatch repair status were compared between EOCRC and late\u2010onset colorectal cancer (LOCRC), with additional stratification by documented family history. Multivariable logistic regression was used to evaluate the independent association between early\u2010onset status and deficient mismatch repair (dMMR). Compared with LOCRC, EOCRC showed less favorable clinicopathological features, including higher proportions of poor differentiation, T4 tumors, nodal involvement, and advanced TNM stage. EOCRC also had a significantly higher prevalence of dMMR. In multivariable analysis, early\u2010onset status was independently associated with dMMR in the overall cohort (adjusted OR, 2.27; 95% CI, 1.60\u20133.22;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and among patients without documented family history (adjusted OR, 1.95; 95% CI, 1.33\u20132.86;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Patterns of MMR protein loss differed according to documented family history status. In conclusion, EOCRC in this Chinese MMR\u2010tested cohort was associated with more advanced clinicopathological features and a higher prevalence of dMMR, supporting routine MMR assessment in young patients with colorectal cancer.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70667","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:14:33Z","timestamp":1785557673000},"page":"2473-2484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deficient Mismatch Repair Represents a Distinct Molecular\u00a0Feature of Early\u2010Onset Colorectal Cancer in\u00a0Chinese Single\u2010Center Cohort"],"prefix":"10.1002","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8180-3814","authenticated-orcid":false,"given":"Deng","family":"Tang","sequence":"first","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Lan","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Su","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Tang","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Natural and Applied Sciences, Synear Molecular Biology Lab Duke Kunshan University  People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiting","family":"Yan","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zhang","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Wang","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences &amp; Forensic Medicine Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21772"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaf238"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33916"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-018-0618-9"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31994"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.13157"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-025-01159-z"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001661"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i5.1736"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00026-3"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000003463"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106780"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/10732748251341524"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znac322"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.70059"},{"key":"e_1_2_12_18_1","first-page":"e42340","article-title":"Early\u2010Onset\/Young\u2010Onset Colorectal Carcinoma: A Comparative Analysis of Morphological Features and Biomarker Profile","volume":"15","author":"Hashmi A. 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