{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:59:41Z","timestamp":1785131981827,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202408080102"],"award-info":[{"award-number":["202408080102"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010564","name":"Deutsches Zentrum f\u00fcr Lungenforschung","doi-asserted-by":"publisher","award":["82DZL002B1"],"award-info":[{"award-number":["82DZL002B1"]}],"id":[{"id":"10.13039\/501100010564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010564","name":"Deutsches Zentrum f\u00fcr Lungenforschung","doi-asserted-by":"publisher","award":["82DZL004C2"],"award-info":[{"award-number":["82DZL004C2"]}],"id":[{"id":"10.13039\/501100010564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    BTB and CNC homolog 1 (BACH1) is a redox\u2010sensitive transcription factor implicated in tumor progression, metabolic reprogramming, and therapy resistance in several cancers. However, its prognostic significance and role in therapy resistance\u00a0in\u00a0non\u2013small cell lung cancer (NSCLC) remain unclear. BACH1 mRNA and protein expression were quantified in resected lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) tissues and matched non\u2010tumor lung tissues and correlated with clinicopathological parameters, adjuvant chemotherapy status, and disease\u2010free survival (DFS). Prognostic value was assessed using Kaplan\u2013Meier and multivariate Cox regression analyses. In\u00a0vitro, BACH1 expression was evaluated in seven NSCLC cell lines. Cisplatin sensitivity was determined by Annexin V apoptosis assays, and BACH1 silencing in H1975 and H1437 cells was used to assess effects on cisplatin response, migration, and colony formation. BACH1 expression was lower in LUAD and LUSC than in matched normal lung tissues but was higher in stage III tumors and in patients receiving adjuvant chemotherapy. In LUAD, high BACH1 expression was associated with shorter DFS, particularly in adjuvant chemotherapy. A significant interaction between BACH1 expression and chemotherapy suggested that the benefit of cisplatin\u2010based treatment differed according to BACH1 status. Across seven NSCLC cell lines,\n                    <jats:italic>BACH1<\/jats:italic>\n                    expression positively correlated with cisplatin resistance (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.44,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035).\n                    <jats:italic>BACH1<\/jats:italic>\n                    silencing enhanced cisplatin\u2010induced cell death, suppressed migration, and clonogenic growth in H1975 and H1437 cells. Collectively, these findings identify BACH1 as a potential prognostic and predictive biomarker in chemotherapy\u2010treated LUAD and support a functional role for BACH1 in mediating cisplatin resistance.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70673","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:13:34Z","timestamp":1785129214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Relevance of\n                    <scp>BACH1<\/scp>\n                    Expression in Non\u2013Small Cell Lung Cancer"],"prefix":"10.1002","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School  Hannover Germany"},{"name":"German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Thoraxklinik at Heidelberg University Hospital  Heidelberg Germany"},{"name":"Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School  Hannover Germany"},{"name":"German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Wrenger","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School  Hannover Germany"},{"name":"German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhang","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School  Hannover Germany"},{"name":"German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Allgaeuer","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Eichhorn","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Thoraxklinik at Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3228-8021","authenticated-orcid":false,"given":"Sabina","family":"Janciauskiene","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School  Hannover Germany"},{"name":"German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"12","article-title":"Cancer Statistics, 2024","volume":"74","author":"Siegel R. 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