{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:31:09Z","timestamp":1793723469341,"version":"4.6.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2027,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer survivors frequently experience cancer\u2010related cognitive impairment (CRCI), but the contributions of different anti\u2010cancer therapies remain unclear. Patients with breast or gynaecological cancer were recruited before any anti\u2010cancer treatment. Cognitive function was assessed by objective and subjective measures pre\u2010treatment (T0), post\u2010treatment (T1), and 1 year after T1 (T2). Objective measures include Hopkins Verbal Learning Test\u2010Revised (HVLT\u2010R), Trail Making Test (TMT), Controlled Oral Word Association Test (COWA), and Mnemonic Similarity Task (MST). Subjective measures include Functional Assessment of Cancer Therapy\u2014Cognitive scale (FACT\u2010Cog) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ\u2010C30). Linear mixed models were performed. Patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009234) were of age 55.4\u2009\u00b1\u200911.6\u2009years. At T1, chemotherapy was associated with worse visual searching and motor speed (TMT\u2010A:\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.36, 95% CI: 0.03\u20130.69), perceived global function (FACT\u2010Cog Global Function:\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.39, 95% CI: \u22120.67 to \u22120.11), and cognitive function (EORTC QLQ\u2010C30:\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.50, 95% CI: \u22120.82 to \u22120.18) compared to endocrine therapy. At T2, endocrine therapy was associated with poorer verbal learning and memory performance (HVLT\u2010R total recall:\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u2009\u22120.40, 95% CI: \u22126 to \u22120.03) and higher perceived cognitive impairments (FACT\u2010Cog PCI:\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.34, 95% CI: 0.05\u20130.63). In conclusion, CRCI may occur during certain types of chemotherapy but appears to ameliorate over time. Ongoing endocrine therapy may have longer\u2010lasting impact on cognitive function. Appropriate counselling for informed decision making and good supportive care is needed.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70691","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T06:20:59Z","timestamp":1786170059000},"page":"85-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Cancer\u2010Related Cognitive Impairments Across Anti\u2010Cancer Therapies in a Predominantly Breast Cancer Cohort"],"prefix":"10.1002","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-5039","authenticated-orcid":false,"given":"Qiqi","family":"Lei","sequence":"first","affiliation":[{"name":"Division of Physical Activity, Cancer Prevention and Survivorship German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, a Partnership Between DKFZ and University Medical Center Heidelberg  Heidelberg Germany"},{"name":"Medical Faculty, University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2095-2426","authenticated-orcid":false,"given":"Martina E.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Division of Physical Activity, Cancer Prevention and Survivorship German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, a Partnership Between DKFZ and University Medical Center Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-4503","authenticated-orcid":false,"given":"Philipp","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Division of Sports Medicine Institute for Sport and Sport Science, TU Dortmund University  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patric","family":"Meyer","sequence":"additional","affiliation":[{"name":"School of Psychology, SRH University of Applied Sciences Heidelberg  Heidelberg Germany"},{"name":"Department for General and Applied Linguistics Ruprecht\u2010Karls\u2010University Heidelberg  Heidelberg Germany"},{"name":"Network Aging Research (NAR), Ruprecht\u2010Karls\u2010University Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2429-4512","authenticated-orcid":false,"given":"Andreas","family":"Schneeweiss","sequence":"additional","affiliation":[{"name":"Division of Gynecological Oncology National Center for Tumor Diseases (NCT) Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5215-5651","authenticated-orcid":false,"given":"Karen","family":"Steindorf","sequence":"additional","affiliation":[{"name":"Division of Physical Activity, Cancer Prevention and Survivorship German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, a Partnership Between DKFZ and University Medical Center Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412690"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyae090"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz410"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2018.1500023"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.16077"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.30833"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70908"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2017-0027"},{"key":"e_1_2_12_10_1","volume-title":"Essentials of Psychological Testing","author":"Cronbach L. 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