{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:30:58Z","timestamp":1793723458642,"version":"4.6.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2027,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    All cases of invasive cervical cancer (ICC) and subsets of high\u2010grade cervical intraepithelial neoplasia grade 2 or 3 (CIN2\/3) and adenocarcinoma in\u00a0situ (AIS) in Norway are tested for 37 human papillomavirus (HPV) genotypes, within a mandatory national surveillance system. We assessed the proportional attribution of HPV types in cervical lesions from predominantly unvaccinated women reported during 2017\u20132021 (baseline population) and the HPV type distribution by vaccination status in vaccine\u2010eligible cases reported during 2017\u20132024. Among baseline CIN2\/3 cases (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093087), 48% were attributable to HPV16\/18, 28% to HPV31\/33\/45, 12% to HPV52\/58 and 8% to other high\u2010risk types (HPV35\/39\/51\/56\/59). For AIS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009550), almost all cases were attributed to HPV16\/18 (91%) and HPV45 (6%). For ICC (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091265), 75% were attributable to HPV16\/18, 15% to HPV31\/33\/45, 3% to HPV52\/58 and 4% to other high\u2010risk types. Among CIN2\/3 cases born 1997 or later (eligible for vaccination at age 11\u201312\u2009years,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009154), HPV16\u2010attribution was higher in unvaccinated cases (49.9%, 95% CI: 33.7\u201366.1) than in cases vaccinated before age 15 (1.1%, 95% CI: 0\u20133.4). In CIN2\/3 cases born 1991\u20131996 (eligible for catch\u2010up vaccination,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091541), HPV16\u2010attribution was 45.7% (95% CI: 41.9\u201349.7) in unvaccinated versus 35.5% (95% CI: 32.5\u201338.6) in vaccinated cases. Minor differences by vaccination status were observed for catch\u2010up\u2010eligible AIS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009445) and ICC (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009135) cases. In conclusion, the baseline genotype distribution in high\u2010grade cervical lesions and ICC in Norway aligns with global data. Strong protection against HPV16\u2010induced CIN2\/3 was seen in women vaccinated before age 15\u2009years.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70712","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:22:38Z","timestamp":1787977358000},"page":"171-186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>HPV<\/scp>\n                    Genotype Distribution in Cervical Cancer and High\u2010Grade Lesions in Norway, and Early Vaccine Impact"],"prefix":"10.1002","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9879-7331","authenticated-orcid":false,"given":"Terese","family":"Bekkevold","sequence":"first","affiliation":[{"name":"Division of Infection Control Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Laake","sequence":"additional","affiliation":[{"name":"Division of Infection Control Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Feiring","sequence":"additional","affiliation":[{"name":"Division of Infection Control Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiane","family":"S\u00f8reng","sequence":"additional","affiliation":[{"name":"The Norwegian HPV Reference Laboratory, Department of Microbiology and Infection Control Akershus University Hospital  Lorenskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gro Kummeneje","family":"Presthus","sequence":"additional","affiliation":[{"name":"The Norwegian HPV Reference Laboratory, Department of Microbiology and Infection Control Akershus University Hospital  Lorenskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenny Cecilie","family":"Alfsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Akershus University Hospital  Lorenskog Norway"},{"name":"Faculty of Medicine, University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Kraus","family":"Christiansen","sequence":"additional","affiliation":[{"name":"The Norwegian HPV Reference Laboratory, Department of Microbiology and Infection Control Akershus University Hospital  Lorenskog Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Hansen","sequence":"additional","affiliation":[{"name":"Division of Infection Control Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Division of Infection Control Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirik","family":"Olsen","sequence":"additional","affiliation":[{"name":"Division of Infection Control Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torstein Gj\u00f8lgali","family":"Frengen","sequence":"additional","affiliation":[{"name":"Division of Infection Control Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Health Management and Health Economics University of Oslo  Oslo Norway"},{"name":"Harvard T.H Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Genieve Monceyron","family":"Jonassen","sequence":"additional","affiliation":[{"name":"Division of Infection Control Norwegian Institute of Public Health  Oslo 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