{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:07:23Z","timestamp":1789016843326,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Aspirin has been used to treat pain and fever for 120\u2009years. Its uses expanded into treating arthritis and prevention of thrombotic events. Its anti\u2010cancer role emerged with observational studies in the 1980's and subsequent cancer review in those treated with aspirin in cardiovascular trials. Two randomised placebo\u2010controlled trials with cancer as an endpoint, the Women's Health Study and CAPP2 provided support. The latter involved 861 carriers of Lynch syndrome (LS) who received either 600\u2009mg aspirin or placebo for 2\u20134\u2009years. Aspirin recipients subsequently had 50% fewer colorectal cancers. CaPP3 randomised 1866 LS carriers to 600\u2009mg, 300\u2009mg or 100\/75\u2009mg daily for 2\u2009years blinded then for 3\u2009years open label. Lynch syndrome cancer and colorectal cancer rate mirrored that in the 600\u2009mg limb of CAPP2. Those on the lowest dose had the fewest cancers in keeping with this being equivalent to 600\u2009mg. The Intention to treat confidence intervals fell within the predefined upper limit of 1.5. A survey of primary care doctors revealed only 62% would agree to prescribe the 600\u2009mg dose regardless of guidance.<\/jats:p>\n                  <jats:p>As a normal dietary component, salicylate is likely to influence multiple pathways. Most interesting is the recent demonstration that low dose aspirin blocks release of thromboxane A2, a product of activated platelets which suppresses T cell function. An international Delphi report has endorsed the daily use of 75\u2013100\u2009mg aspirin in adults with Lynch syndrome prior to old age when adverse effects become a greater concern.<\/jats:p>","DOI":"10.1002\/ijc.70714","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:10:21Z","timestamp":1789013421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Less More? An Update on Aspirin for Cancer Prevention in Lynch Syndrome From the Cancer Prevention Programme\u2014\n                    <scp>CaPP<\/scp>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9823-2322","authenticated-orcid":false,"given":"John","family":"Burn","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute, Centre for Life Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8752-8785","authenticated-orcid":false,"given":"D. Timothy","family":"Bishop","sequence":"additional","affiliation":[{"name":"Division of Haematology and Immunology Leeds Institute of Medical Research at St James's, University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio231232a0"},{"issue":"15","key":"e_1_2_14_3_1","first-page":"4399","article-title":"Colorectal Cancer Risk, Chronic Illnesses, Operations, and Medications: Case Control Results From the Melbourne Colorectal Cancer Study","volume":"48","author":"Kune G. A.","year":"1988","journal-title":"Cancer Research"},{"key":"e_1_2_14_4_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1056\/NEJM199509073331001","article-title":"Aspirin and the Risk of Colorectal Cancer in Women","volume":"333","author":"Giovannucci E.","year":"1995","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940\u20106207.CAPR\u201011\u20100106"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30366\u20104"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(12)70109\u20102"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)61049\u20100"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(26)00114\u20107"},{"key":"e_1_2_14_10_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/bmj.313.7048.36","article-title":"Trials to Assess Equivalence: The Importance of Rigorous Methods","volume":"313","author":"Jones B.","year":"1996","journal-title":"BMJ"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010159\u20102\u2010201307160\u201000002"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)62110\u20101"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.9952"},{"key":"e_1_2_14_14_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/bjc.2011.172","article-title":"Body Mass Index in Early Adulthood and Colorectal Cancer Risk for Carriers and Non\u2010Carriers of Germline Mutations in DNA Mismatch Repair Genes","volume":"105","author":"Win A. K.","year":"2011","journal-title":"British Journal of Cancer"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051736"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31133\u20104"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvae064"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101909"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021633"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn485"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102016\u2010312043"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01843\u20108"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.090514"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(98)04311\u20106"},{"key":"e_1_2_14_25_1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1158\/1940-6207.CAPR-11-0106","article-title":"A Randomized Placebo\u2010Controlled Prevention Trial of Aspirin and\/or Resistant Starch in Young People With Familial Adenomatous Polyposis","volume":"4","author":"Burn J.","year":"2011","journal-title":"Cancer Prevention Research (Philadelphia, Pa.)"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16\u20100577"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1995.1020"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaa114"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052717"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7732374"},{"key":"e_1_2_14_31_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1079\/PNS19980030","article-title":"Diet and Cancer Prevention: The Concerted Action Polyp Prevention (CAPP) Studies","volume":"57","author":"Burn J.","year":"1998","journal-title":"Proceedings of the Nutrition Society"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010020\u201000112\u20105"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.083"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106506"},{"key":"e_1_2_14_35_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2307\/3870506","article-title":"Salicylic Acid Interferes With Tobacco Mosaic Virus Replication via a Nove1 Salicylhydroxamic Acid Sensitive Mechanism","volume":"9","author":"Chivasa S.","year":"1997","journal-title":"Plant Cell"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008626\u20107"},{"key":"e_1_2_14_37_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmr.2025.100109","article-title":"Platelet Activation, Aspirin and Cancer: From Basic Science to Clinical Trials","volume":"78","author":"Patrono C.","year":"2026","journal-title":"Pharmacological Reviews"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015266.pub2"},{"key":"e_1_2_14_39_1","article-title":"Lynch Syndrome Network Consensus (LYNSYNC). International Guidelines on Clinical Management, Surveillance and Prevention","author":"Cavestro G. M.","year":"2026","journal-title":"Nature Cancer"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70714","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:10:23Z","timestamp":1789013423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":38,"alternative-id":["10.1002\/ijc.70714"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70714","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"2025-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ijc.70714"}}