{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T10:25:21Z","timestamp":1787394321135,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504488"],"award-info":[{"award-number":["82504488"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Body Roundness Index (BRI) is a novel measure of visceral and total body fat. Its association with multiple cancers and predictive value relative to Body Mass Index (BMI) remain unclear. The associations between BRI and the incidence and mortality (specific, overall and all causes death) risk of 23 site\u2010specific cancers were evaluated using Cox proportional hazards models in UK Biobank participants. Restricted cubic spline (RCS) was further employed to assess the nonlinear association between BRI and 23 cancers. Additionally, we used the C\u2010index and NRI to compare the predictive ability of BRI and BMI for cancer incidence and mortality risk. During a median follow\u2010up of 13.7\u2009years, higher BRI significantly increased overall cancer risk (hazard ratio [HR]\u2009=\u20091.04, 95% confidence interval [CI]: 1.03\u20131.14), persisting after BMI or residual adjustment. Positive linear associations were observed for 10 cancers (esophagus, stomach, colorectal, gallbladder, pancreas, corpus uteri, kidney, bladder, thyroid, and Hodgkin's; HRs: 1.05\u20131.31). Nonlinear patterns included inverted U\u2010shaped (breast, prostate) and U\u2010shaped (liver) associations (\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>non\u2010linear<\/jats:sub>\n                    &lt;\u20090.05). Higher BRI also predicted increased overall cancer mortality (HR\u2009=\u20091.04, 95% CI: 1.02\u20131.06) and all\u2010cause mortality (HR\u2009=\u20091.07, 95% CI: 1.05\u20131.09), especially among breast and prostate cancer patients. However, BRI and BMI showed comparable predictive ability for both incidence and mortality (all\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>\u0394<\/jats:italic>\n                      C\u2010indices\n                    <\/jats:sub>\n                    &gt;\u20090.05). BRI is significantly associated with the incidence and mortality of various cancers. With predictive performance comparable to BMI, BRI serves as a valuable anthropometric indicator for assessing cancer risks.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70716","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T09:49:18Z","timestamp":1787392158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Body Roundness Index a Predictor of Cancer Incidence and Mortality? A Prospective Cohort Study"],"prefix":"10.1002","author":[{"given":"Yangyang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Qiantang District Center for Disease Control and Prevention  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuting","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizi","family":"Chen","sequence":"additional","affiliation":[{"name":"First Clinical Medical College Zhejiang Chinese Medical 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