{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T05:25:10Z","timestamp":1787376310033,"version":"build-2736575974"},"reference-count":95,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Patient\u2010derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in\u00a0vitro expansion of material from cancer patients in a considerably short period of time. These three\u2010dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular functions. Based on these characteristics, there has been a growing interest in exploring the potential of these models for translational research, as is the case with colorectal, pancreatic, prostate, breast, lung, and bladder cancer, among other solid tumors. A key application of cancer\u2010specific organoids is the development of patient\u2010matched platforms for drug testing, thus bringing the hype of personalized medicine closer to clinical practice. Over the past decade, clinical trials based on organoid\u2010guided drug screening have been conducted in several cancer models with promising results. Nonetheless, further progress is still needed in this field, as there are still few studies that rigorously apply the results of real\u2010time PDO tests to assist in clinical decision\u2010making. In this review, we provide a focused synthesis of the most relevant clinical trials using PDO as well as their application for biobanking.<\/jats:p>","DOI":"10.1002\/ijc.70717","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T04:47:31Z","timestamp":1787374051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Translation of Patient\u2010Derived Organoids: Perspectives for Personalized Therapy in Cancer"],"prefix":"10.1002","author":[{"given":"Haiyan","family":"Yue","sequence":"first","affiliation":[{"name":"Department for BioMedical Research (DBMR), Urology Research Laboratory University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2707-7678","authenticated-orcid":false,"given":"Daniele","family":"Carchidi","sequence":"additional","affiliation":[{"name":"Department for BioMedical Research (DBMR), Urology Research Laboratory University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Schmucker","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Seiler","sequence":"additional","affiliation":[{"name":"Department for BioMedical Research (DBMR), Urology Research Laboratory University of Bern  Bern Switzerland"},{"name":"Hospital Centre Biel, Urology  Biel Switzerland"},{"name":"Department of Urology Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Urology Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Lindenhofspital Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-8398","authenticated-orcid":false,"given":"Catarina","family":"Macedo\u2010Silva","sequence":"additional","affiliation":[{"name":"Department for BioMedical Research (DBMR), Urology Research Laboratory University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Kruithof\u2010de Julio","sequence":"additional","affiliation":[{"name":"Department for BioMedical Research (DBMR), Urology Research Laboratory University of Bern  Bern Switzerland"},{"name":"Department of Urology Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"},{"name":"Department for BioMedical Research (DBMR) Translational Organoid Resource (TOR), University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/biot.202000463","article-title":"Historical Evolution of Spheroids and Organoids, and Possibilities of Use in Life Sciences and Medicine","volume":"16","author":"Sakalem M. 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