{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:14:32Z","timestamp":1788174872323,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000462658"],"award-info":[{"award-number":["RS\u20102024\u201000462658"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201000558296"],"award-info":[{"award-number":["RS\u20102025\u201000558296"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201024803025"],"award-info":[{"award-number":["RS\u20102025\u201024803025"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Evidence on discordant familial cancer associations and their relevance in non\u2010Western populations remains limited. This study assessed concordant and discordant cancer risks across major cancer sites in Korean women by comparing individuals with and without a family history of cancer. In total, 5,015,485 cancer\u2010free women aged \u2265\u200940\u2009years who participated in the national breast cancer screening program were included. Participants reported a family history of stomach, colorectal, liver, breast, cervical, or other cancers at screening. The risks of overall, site\u2010specific, concordant (same cancer site as the family history), and discordant cancers (different cancer sites from the family history) were evaluated. Overall, a family history of any cancer was associated with a higher hazard of cancer (HR, 1.11; 95% CI, 1.10\u20131.12), with similar associations for cancers diagnosed before age 50\u2009years (HR, 1.12; 95% CI, 1.09\u20131.14) and those diagnosed at age 50\u2009years or older (HR, 1.13; 95% CI, 1.12\u20131.14). Elevated hazards associated with a family history were observed for most cancer sites, except for cervical, kidney, and brain cancers. Concordant associations were observed for gastric, colorectal, breast, and liver cancers (HRs, 1.36\u20132.43), whereas cervical cancer showed no significant concordant association. Modest but statistically significant discordant associations were observed across the five family history cancer types (HRs, 1.05\u20131.13). These associations were generally consistent across age groups. A family history of cancer was associated with both overall and site\u2010specific cancer risk, with stronger associations for concordant cancers and more modest associations for discordant cancers.<\/jats:p>","DOI":"10.1002\/ijc.70730","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:21:06Z","timestamp":1788171666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Family History of Cancer and Risks of Concordant and Discordant Cancers: A Nationwide Cohort Study of Korean Women"],"prefix":"10.1002","author":[{"given":"Junghyun","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine Hanyang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hanyang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hanyang University College of Medicine  Seoul Republic of Korea"},{"name":"Hanyang Institute of Bioscience and Biotechnology, Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray F.","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"10352","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0140-6736(22)01438-6","article-title":"The Global Burden of Cancer Attributable to Risk Factors, 2010\u201019: A Systematic Analysis for the Global Burden of Disease Study 2019","volume":"400","author":"GBD 2019 Cancer Risk Factors Collaborators","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41698-021-00176-1","article-title":"Will Polygenic Risk Scores for Cancer Ever Be Clinically Useful?","volume":"5","author":"Sud A.","year":"2021","journal-title":"NPJ Precis Oncol"},{"issue":"3","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.suc.2020.02.012","article-title":"Cancer Genetics","volume":"100","author":"Van Cott C.","year":"2020","journal-title":"Surgical Clinics of North America"},{"issue":"11","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nrc.2017.82","article-title":"Genome\u2010Wide Association Studies of Cancer: Current Insights and Future Perspectives","volume":"17","author":"Sud A.","year":"2017","journal-title":"Nature Reviews. 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J.","year":"2022","journal-title":"Scientific Reports"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.70730","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.70730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:21:11Z","timestamp":1788171671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.70730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":36,"alternative-id":["10.1002\/ijc.70730"],"URL":"https:\/\/doi.org\/10.1002\/ijc.70730","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2026-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ijc.70730"}}