{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:12:21Z","timestamp":1788779541892,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG\u201024\u20101321373\u201001\u2010ESED"],"award-info":[{"award-number":["RSG\u201024\u20101321373\u201001\u2010ESED"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA164974"],"award-info":[{"award-number":["U01 CA164974"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In the United States (US), cardiometabolic conditions and aggressive breast cancers are both more common among Black women than White women. Using data from 57,453 participants in the Black Women's Health Study (BWHS), we prospectively evaluated associations of body mass index (BMI), Type 2 diabetes, hypertension, and hypercholesterolemia with incidence of breast cancer. Pathology records were used to classify cases by estrogen receptor (ER) status and subtype (luminal A\u2010like, luminal B\u2010like, HER2\u2010overexpressed, and triple negative). We used competing risk Cox proportional hazards models to estimate hazard ratios (HR), adjusting for age, reproductive factors, and lifestyle factors. Among postmenopausal women, BMI \u2265\u200930\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (vs. &lt;\u200925\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) was associated with increased risks of ER+ (HR\u2009=\u20091.35, 95% CI\u2009=\u20091.15\u20131.59) breast cancer and the luminal A\u2010like subtype (HR\u2009=\u20091.54, 95% CI\u2009=\u20091.19\u20131.98). No other cardiometabolic factors were associated with breast cancer subtypes. Relative to those with no cardiometabolic factors, postmenopausal women with \u2265\u20093 cardiometabolic conditions had a 43% higher risk of ER+ cancer (95% CI\u2009=\u20091.04\u20131.97) and a 38% lower risk of ER\u2212 cancer (95% CI\u2009=\u20090.37\u20131.02;\n                    <jats:italic>p<\/jats:italic>\n                    \u2010heterogeneity\u2009=\u20090.006). Analyses of all possible combinations of 2 or 3 factors resulted in HRs &gt;\u20091.0 for analyses of ER+ breast cancer and HRs not significantly different from 1.0 for analyses of ER\u2212 breast cancer. There were no statistically significant findings among premenopausal women. In this large cohort of Black women, poorer cardiometabolic health was associated with higher ER+ and lower ER\u2212 breast cancer risk among postmenopausal women. These divergent associations support a role for metabolic\u2013endocrine crosstalk in breast cancer etiology.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70734","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:54:40Z","timestamp":1788778480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiometabolic Health and Risk of Breast Cancer Subtypes Among\n                    <scp>US<\/scp>\n                    Black Women"],"prefix":"10.1002","author":[{"given":"Yifei","family":"Shan","sequence":"first","affiliation":[{"name":"Slone Epidemiology Center Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Rothbard","sequence":"additional","affiliation":[{"name":"Slone Epidemiology Center Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Slone Epidemiology Center Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie R.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Slone Epidemiology Center Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Department of Medicine, Sections of Cardiovascular Medicine and Preventive Medicine &amp; Epidemiology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4843-4655","authenticated-orcid":false,"given":"Mollie E.","family":"Barnard","sequence":"additional","affiliation":[{"name":"Slone Epidemiology Center Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Department of Medicine, Section of Hematology\/Oncology Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd14.160287"},{"key":"e_1_2_12_3_1","unstructured":"National Center for Health Statistics (U.S.) National Center for Health Services Research \u201cHealth United States \u201d1975\u20131976\/77 1979: DHEW Publication No (HRA). 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