{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:52:27Z","timestamp":1792072347009,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We conducted a controlled trial among 5626 early adolescent women vaccinated in 2007\u20132009 against human papillomavirus (HPV) types 16\/18 to evaluate the impact of high\u2010intensity versus low\u2010intensity cervical screening, respectively at ages 22\/25\/28 and 28\u2009years with squamous\u2010cell intraepithelial lesions (SILs) as the end\u2010point. Over the 16\u2010year follow\u2010up, most of the cytologically and\/or histologically confirmed low\u2010grade and high\u2010grade SILs were associated with non\u2010vaccine\u2010targeted, medium oncogenicity HPV types 33\/35\/52\/58 belonging to clade A9. The low\u2010intensity cervical screening was non\u2010inferior to the high\u2010intensity screening in the identification of these lesions. Possibly, the transition from cervical infections with vaccine\u2010covered HPV types to infections with non\u2010vaccine\u2010covered HPV types contributes to more manageable occurrence of the screen\u2010detected cervical lesions. Reduction of cervical screening among vaccinated women to a minimum may be warranted to balance the harm\u2014benefit ratio of screening.<\/jats:p>","DOI":"10.1002\/ijc.70753","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:35:53Z","timestamp":1792071353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Controlled Trial of Cervical Cancer Screening Frequency Among Human Papillomavirus Vaccinated Women\n                    <scp>II<\/scp>\n                    : Cervical Pre\u2010Cancer End\u2010Points by Specific Non\u2010Vaccine\n                    <scp>HPV<\/scp>\n                    Types"],"prefix":"10.1002","author":[{"given":"Matti","family":"Lehtinen","sequence":"first","affiliation":[{"name":"Centre for Cervical Cancer Elimination, Department of Clinical Science Intervention and Technology, Karolinska Institutet  Stockholm Sweden"},{"name":"FICAN\u2010Mid  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4248-1880","authenticated-orcid":false,"given":"M\u00f2nica Ortega","family":"Llobet","sequence":"additional","affiliation":[{"name":"Centre for Cervical Cancer Elimination, Department of Clinical Science Intervention and Technology, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Eriksson","sequence":"additional","affiliation":[{"name":"FICAN\u2010Mid  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Baussano","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer (IARC\/WHO) Early Detection, Prevention and, Infections Branch  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0514-7226","authenticated-orcid":false,"given":"Miriam","family":"Elfstr\u00f6m","sequence":"additional","affiliation":[{"name":"Centre for Cervical Cancer Elimination, Department of Clinical Science Intervention and Technology, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Ghaderi","sequence":"additional","affiliation":[{"name":"Centre for Cervical Cancer Elimination, Department of Clinical Science Intervention and Technology, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9065-4734","authenticated-orcid":false,"given":"Penelope","family":"Gray","sequence":"additional","affiliation":[{"name":"Centre for Cervical Cancer Elimination, Department of Clinical Science Intervention and Technology, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Harjula","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health, Faculty of Medicine Oulu University  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Heikkil\u00e4","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Hokkanen","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health, Faculty of Medicine Oulu University  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Kares","sequence":"additional","affiliation":[{"name":"FICAN\u2010Mid  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Lagheden","sequence":"additional","affiliation":[{"name":"Centre for Cervical Cancer Elimination, Department of Clinical Science Intervention and Technology, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Nieminen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"S\u00f6derlund\u2010Strand","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Microbiology Sk\u00e5ne University Hospital, Lund, Lund University  Lund 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