{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:57:05Z","timestamp":1790773025003,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K20503"],"award-info":[{"award-number":["25K20503"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020107","name":"Hirose Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Short\u2010term exposure to fine particulate matter (PM2.5) is an established risk factor for cardiopulmonary mortality, but its acute association with cancer mortality remains poorly characterized. We examined associations between short\u2010term PM2.5 fluctuations and daily all\u2010cancer and site\u2010specific mortality across all 47 Japanese prefectures from January 1, 2013, to December 31, 2022. Using a nationwide time\u2010stratified case\u2010crossover design, we fitted prefecture\u2010specific conditional quasi\u2010Poisson regression models and pooled the estimates by random\u2010effects meta\u2010analysis, expressing associations as the excess relative risk (ERR) per 10\u2009\u03bcg\/m\n                    <jats:sup>3<\/jats:sup>\n                    increase in PM2.5 (lag 0\u20132\u2009days). Sensitivity analyses varied lag structures, meteorological spline specifications, and co\u2010pollutant adjustment. A 10\u2009\u03bcg\/m\n                    <jats:sup>3<\/jats:sup>\n                    increase in short\u2010term PM2.5 was associated with a 0.88% increase in all\u2010cancer mortality (95% CI: 0.57\u20131.18;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The association was consistent across sex, age, and primary site (all interaction\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.40), with significant estimates for breast (ERR 2.06%), colorectal (1.06%), stomach (0.81%), and lung (0.77%) cancers. Associations attenuated with longer moving\u2010average windows and were no longer statistically significant from lag 0\u20135 onward. A measurable fraction of cancer deaths was attributable to PM2.5 above the WHO 24\u2010h guideline (15\u2009\u03bcg\/m\n                    <jats:sup>3<\/jats:sup>\n                    ), with the largest fractions tracking prefecture\u2010specific coefficients rather than ambient concentration. These findings indicate that short\u2010term PM2.5 exposure is associated with higher daily mortality across diverse cancer types in Japan, even at relatively low ambient levels. Because the individual\u2010level effect size is small and attenuated to non\u2010significance after adjustment for either NO\n                    <jats:sub>2<\/jats:sub>\n                    or SO\n                    <jats:sub>2<\/jats:sub>\n                    , these findings are best interpreted as supporting population\u2010level air\u2010quality measures rather than individual clinical intervention.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70761","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:58:08Z","timestamp":1790769488000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010Term PM2.5 Exposure and Daily Cancer Mortality Across 47 Japanese Prefectures: A Nationwide Time\u2010Stratified Case\u2010Crossover Study, 2013\u20132022"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-2225","authenticated-orcid":false,"given":"Tshewang","family":"Gyeltshen","sequence":"first","affiliation":[{"name":"Research Center for Health Policy and Economics, Hitotsubashi Institute for Advanced Study (HIAS) Hitotsubashi University  Tokyo Japan"},{"name":"Department of Global Health Policy, School of International Health The University of Tokyo  Tokyo Japan"},{"name":"Division of Population Data Science, National Cancer Centre Institute for Cancer Control  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminu Kende","family":"Abubakar","sequence":"additional","affiliation":[{"name":"Research Center for Health Policy and Economics, Hitotsubashi Institute for Advanced Study (HIAS) Hitotsubashi University  Tokyo Japan"},{"name":"Division of Population Data Science, National Cancer Centre Institute for Cancer Control  Tokyo Japan"},{"name":"Graduate School of Public Health St.\u00a0Luke's International University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Jamil","sequence":"additional","affiliation":[{"name":"Research Center for Health Policy and Economics, Hitotsubashi Institute for Advanced Study (HIAS) Hitotsubashi University  Tokyo Japan"},{"name":"Division of Population Data Science, National Cancer Centre Institute for Cancer Control  Tokyo Japan"},{"name":"Graduate School of Public Health St.\u00a0Luke's International University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Research Center for Health Policy and Economics, Hitotsubashi Institute for Advanced Study (HIAS) Hitotsubashi University  Tokyo Japan"},{"name":"Graduate School of Public Health St.\u00a0Luke's International University  Tokyo 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