{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:42:12Z","timestamp":1792222932161,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    BRCAness, a phenotype associated with homologous recombination deficiency, has not been fully characterized in triple\u2010negative breast cancer (TNBC) with residual disease after neoadjuvant chemotherapy (NAC), especially regarding prognosis and regimen\u2010specific postoperative management. We analyzed 137 patients with TNBC who had residual invasive disease after NAC. BRCAness status was assessed in surgical specimens using multiplex ligation\u2010dependent probe amplification (MLPA). Its associations with clinicopathological features and survival were evaluated according to NAC regimen, and prognostic models for disease\u2010free survival (DFS) and overall survival (OS) were developed by combining BRCAness with clinicopathological variables. BRCAness was identified in 42.3% of tumors and was associated with high histological grade, high Ki\u201067, and perineural invasion. Patients with BRCAness\u2010positive tumors had worse survival than those with BRCAness\u2010negative tumors (5\u2010year DFS, 50.0% vs. 68.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.020; 5\u2010year OS, 58.6% vs. 78.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.014). This prognostic effect was evident in patients treated with anthracycline\u2010based NAC, but not in those treated with platinum\u2010based regimens. Models incorporating BRCAness showed good discrimination (DFS C\u2010index, 0.70; 95% CI, 0.62\u20130.78; OS C\u2010index, 0.75; 95% CI, 0.69\u20130.81). Among BRCAness\u2010positive patients who had received anthracycline\u2010based NAC, adjuvant chemotherapy was associated with better survival (5\u2010year DFS, 55.6% vs. 27.3%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035; 5\u2010year OS, 66.7% vs. 36.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.023). BRCAness was associated with poorer outcome in residual TNBC after NAC and may help identify patients with different prognoses and postoperative treatment patterns.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70765","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:23:58Z","timestamp":1792221838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>BRCAness<\/scp>\n                    \u2010Driven Prognostic Model and Regimen\u2010Specific Therapeutic Implications in Triple\u2010Negative Breast Cancer With Residual Disease After Neoadjuvant Chemotherapy"],"prefix":"10.1002","author":[{"given":"Hangcheng","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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 Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9432-1902","authenticated-orcid":false,"given":"Fei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8903-3666","authenticated-orcid":false,"given":"Pin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-1266","authenticated-orcid":false,"given":"Qiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-439X","authenticated-orcid":false,"given":"Bo","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center\/National Clinical Research 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