{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:50:45Z","timestamp":1791877845692,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Available epidemiological evidence shows that many cancers share familial risks, and this is increasingly confirmed by data on shared pathogenic germline gene variants between cancers. We decided to harness the world's largest resource on familial cancer to assess discordant familial risks for female breast (BC), prostate (PC), colorectal (CRC), and lung (LC) cancers with any of 22 different cancers in first\u2010degree relatives (proband cancers). Familial relative risk was calculated as standardized incidence ratio (SIR) when either one proband or 2 or more (2+) probands were found in a family to distinguish low\u2010 and high\u2010risk associations. Discordant familial associations of BC were significant for 12 1\u2010proband and 5 2+ proband cancers. For PC, the numbers were 11 and 4; for CRC, they were 8 and 4; and for LC, they were 15 and 5. The results with large case numbers showed that BC, CRC, and LC associated with each other, but the familial association between PC and LC was negative. Many known or novel associations with possible genetic causes were found, including lobular BC with stomach cancer, PC with kidney cancer, CRC with squamous cell skin and thyroid cancers, and LC with gallbladder and endocrine tumors, the most common of which were parathyroid adenomas. Also, LC associations with esophageal and cervical cancers were\u00a0unlikely to be due to smoking alone and require additional explanations. In conclusion, 2\/3 of discordant associations could suggest low\u2010risk genetic and environmental causation and 1\/3 high\u2010risk genetic causation, both waiting for experimental proof.<\/jats:p>","DOI":"10.1002\/ijc.70781","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:36:36Z","timestamp":1791876996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Familial Cancers Associated With Cancers of the Breast, Prostate, Colorectum, and Lung in Sweden"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7600-7143","authenticated-orcid":false,"given":"Frantisek","family":"Zitricky","sequence":"first","affiliation":[{"name":"Biomedical Center, Faculty of Medicine Charles University Pilsen  Pilsen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"},{"name":"University Clinic Primary Care Sk\u00e5ne University Hospital  Region Sk\u00e5ne Sweden"},{"name":"Department of Family and Community Medicine McGovern Medical School, The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"},{"name":"University Clinic Primary Care Sk\u00e5ne University Hospital  Region Sk\u00e5ne Sweden"},{"name":"Department of Family and Community Medicine McGovern Medical School, The University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akseli","family":"Hemminki","sequence":"additional","affiliation":[{"name":"Cancer Gene Therapy Group, Translational Immunology Research Program University of Helsinki  Helsinki Finland"},{"name":"Comprehensive Cancer Center Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asta","family":"F\u00f6rsti","sequence":"additional","affiliation":[{"name":"Hopp Children's Cancer Center (KiTZ)  Heidelberg Germany"},{"name":"Division of Pediatric Neurooncology German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-3316","authenticated-orcid":false,"given":"Kari","family":"Hemminki","sequence":"additional","affiliation":[{"name":"Biomedical Center, Faculty of Medicine Charles University Pilsen  Pilsen Czech Republic"},{"name":"Division of Cancer Epidemiology German Cancer Research Center (DKFZ)  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ajmg.c.30026","article-title":"Inherited Predisposition to Cancer: A Historical Overview","volume":"129","author":"Lynch H. 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