{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:42:13Z","timestamp":1792665733460,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01KU1002A\u2010J"],"award-info":[{"award-number":["01KU1002A\u2010J"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fifty years ago, Zech et\u00a0al. in this journal described for the first time the t(8;14) as a recurrent chromosomal aberration in Burkitt lymphoma (BL). Nevertheless, in regions where BL is not endemic, a subset of lymphomas with features of BL lacks the t(8;14)\/\n                    <jats:italic>IG<\/jats:italic>\n                    ::\n                    <jats:italic>MYC<\/jats:italic>\n                    and instead represents high\u2010grade B\u2010cell lymphoma with 11q aberration (HGBCL,11q). As Zech et\u00a0al. already noted the cell line BJAB to be an exception as BL from a 5\u2010year Kenyan girl in being EBV\u2010negative, lacking the t(8;14) but showing a chromosome 11 aberration, we here revisited and updated the molecular features of BJAB. Genetic analyses confirmed its East African origin and absence of\n                    <jats:italic>IG<\/jats:italic>\n                    ::\n                    <jats:italic>MYC<\/jats:italic>\n                    but unraveled complex 11q aberrations, including gains in 11q14.1\u2010q23.1, loss of 11q23.2qter, and, notably, a nonreciprocal\n                    <jats:italic>5\u2032KMT2A<\/jats:italic>\n                    ::\n                    <jats:italic>CLTC3\u2032<\/jats:italic>\n                    \u2010fusion. The mutational landscape contained genes typically mutated in mature B\u2010cell lymphomas but no driver genes restricted to BL. Therefore, we hypothesize that BJAB derives from an African HGBCL,11q. To investigate the presence of this entity in East Africa, we analyzed 24 cases with Burkitt or high\u2010grade morphology diagnosed at Kenyatta National Hospital. Twenty cases fulfilled the morphological and immunophenotypical criteria for the diagnosis of BLs (11 EBV\u2010positive, 9 EBV\u2010negative). Genetic testing in these cases identified one EBV\u2010negative case (20\u2009years) as MYC\u2010nonrearranged but displaying the typical 11q pattern, thus representing HGBCL,11q. Among the four HGBCL with intermediate features, two showed gains in 11q including the region typically deleted in HGBCL,11q. Our findings establish HGBCL,11q as a relevant differential molecular diagnosis to Burkitt lymphoma in sub\u2010Saharan Africa.\n                  <\/jats:p>","DOI":"10.1002\/ijc.70788","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:17:17Z","timestamp":1792664237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010Grade B\u2010Cell Lymphoma With 11q Aberration in Africa: A Differential Diagnosis in Cases With Features of Endemic Burkitt Lymphoma"],"prefix":"10.1002","author":[{"given":"Timothy","family":"Onyuma","sequence":"first","affiliation":[{"name":"Pathology Department Kenyatta National Hospital  Nairobi Kenya"},{"name":"Section of Pathology, Department of Medical Biotechnology University of Siena  Siena 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Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schlesner","sequence":"additional","affiliation":[{"name":"Biomedical Informatics, Data Mining and Data Analytics University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Siciliano","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Medical Biotechnology University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Vannucchi","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Medical Biotechnology University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabea","family":"Wagener","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Ulm University and Ulm University Medical Center  Ulm 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Genetics, Ulm University and Ulm University Medical Center  Ulm Germany"},{"name":"German Center for Child and Adolescent Health (DZKJ), Partner Site Ulm  Ulm Germany"},{"name":"Center for Rare Diseases (ZSE) Ulm University Medical Center  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170108"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/237033a0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.24.7824"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000404\u20103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001620\u20102"},{"key":"e_1_2_11_6_2","unstructured":"Erratum inLeukemia37 no.9(2023):1944\u20131951 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