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One defining diagnostic feature of Alzheimer's disease is the deposition of beta\u2010amyloid as extracellular plaques, primarily in the hippocampus. This raises the question: are there natural protective agents that prevent beta\u2010amyloid from depositing, and is it loss of this protection that leads to onset of disease? Proteins in cerebrospinal fluid (CSF) have been suggested to act as just such natural protective agents. 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