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From a high\u2010throughput screen, we previously identified 16 full\u2010length (FL) LC stabilizers from five distinct chemotypes. We then obtained structural biological information on two classes of hits, coumarins and hydantoins, revealing that both chemotypes bind to a pocket at the V<jats:sub>L<\/jats:sub>\u2212V<jats:sub>L<\/jats:sub> interface of the FL LC dimer. Here, we report crystal structures of three screening hits from two other chemotypes, diaryl hydrazones and sulfones, in complex with an amyloidogenic FL LC. While two of these hits bind to the previously identified pocket, one diaryl hydrazone binds to a different pocket bisected by the C<jats:sub>2<\/jats:sub> symmetry axis of the dimer. 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