{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:30:30Z","timestamp":1790299830600,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate high\u2010risk human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) infection clearance rates following successful cold knife conization and factors predictive of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> clearance among patients with cervical intraepithelial neoplasm grade 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The present retrospective study analyzed clinical data from patients aged at least 45\u00a0years with cervical intraepithelial neoplasm grade 3 who had undergone successful cold knife conization and attended regular follow\u2010up at Peking Union Medical College Hospital, China, between January 1, 2002 and December 31, 2012. <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> clearance rates and potential indicators for <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> clearance were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 156 patients were included; persistent high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection was recorded in 78 (50.0%), 45 (28.8%), 35 (22.4%), 24 (15.4%), and 21 (13.5%) patients at 4, 8, 12, 18, and 24\u00a0months after conization, respectively. Clearance rates were significantly lower among patients aged at least 55\u00a0years compared with younger patients, with increased odds of persistent <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection at 8\u00a0months (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 4.038; 95% confidence interval [CI] 1.766\u201310.839), 12\u00a0months (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.923; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.450\u201316.604), 18\u00a0months (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.957; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.031\u201317.469), and 24\u00a0months (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.327; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.909\u201317.971) compared with patients aged 45\u201349\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Age was a prognostic factor for post\u2010operative high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection clearance. Lower clearance rates were observed among patients aged at least 55\u00a0years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12000","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T05:56:09Z","timestamp":1500616569000},"page":"47-52","source":"Crossref","is-referenced-by-count":15,"title":["High\u2010risk human papillomavirus infection clearance following conization among patients with cervical intraepithelial neoplasm grade 3 aged at least 45\u00a0years"],"prefix":"10.1002","volume":"136","author":[{"given":"Guorui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghe","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking Union Medical College Hospital 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