{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:57:03Z","timestamp":1773298623883,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MTA-PTE Human Reproduction Scientific Research Group, Hungary"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the effect of furosemide on hypertension and edema in patients with pre\u2010eclampsia experiencing high cardiac output.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present cohort study enrolled patients with pre\u2010eclampsia who were admitted to the pregnancy pathology unit of the Department of Obstetrics and Gynecology, University of P\u00e9cs, Hungary, between January 1 and December 31, 2015. Eligible patients had singleton pregnancies with no fetal anomalies, high blood volume, visible edema, and a hematocrit concentration below 37\u00a0L\/L. Blood pressure was measured and impedance cardiography was used to determine cardiac output for all patients before they received a 40\u2010mg dose of furosemide; after 60\u00a0minutes blood pressure and cardiac output were measured again.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study enrolled 14 patients. Lower cardiac output (<jats:italic>P<\/jats:italic>=0.002), systolic blood pressure (<jats:italic>P<\/jats:italic>=0.002), and diastolic blood pressure (<jats:italic>P<\/jats:italic>=0.002) were recorded after furosemide administration, with patient heart rates remaining stable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The heart\u2010rate stability suggests that the change of cardiac output was due to a decrease in blood volume. These data suggest that diuretics could be useful in the management of late\u2010onset pre\u2010eclampsia, indicating that an increase in water retention could play a role in the development of late\u2010onset pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12019","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T05:56:09Z","timestamp":1500616569000},"page":"87-90","source":"Crossref","is-referenced-by-count":20,"title":["Preliminary study of the effects of furosemide on blood pressure during late\u2010onset pre\u2010eclampsia in patients with high\u00a0cardiac output"],"prefix":"10.1002","volume":"136","author":[{"given":"P\u00e9ter","family":"Tam\u00e1s","sequence":"first","affiliation":[{"name":"Doctoral School of Health Sciences Faculty of Health Sciences University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Hantosi","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences Faculty of Health Sciences University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1lint","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"MTA\u2010PTE Human Reproduction Scientific Research Group  P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Ifi","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences Faculty of Health Sciences University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Betlehem","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences Faculty of Health Sciences University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"B\u00f3dis","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences Faculty of Health Sciences University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"MTA\u2010PTE Human Reproduction Scientific Research Group  P\u00e9cs Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767050903258746"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-015-0595-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00071.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.24.3183"},{"key":"e_1_2_8_6_1","first-page":"593","article-title":"Plasma volume contraction: A significant factor in both pregnancy\u2010induced hypertension (pre\u2010eclampsia) and chronic hypertension in pregnancy","volume":"48","author":"Gallery EMD","year":"1979","journal-title":"Q J Med"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.17.6.1072"},{"key":"e_1_2_8_8_1","first-page":"1061","article-title":"Maternal hemodynamics in normal and preeclamptic pregnancies. 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