{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:24:05Z","timestamp":1761989045366,"version":"3.28.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To determine the proportion of patients diagnosed with cervical cancer or cervical intraepithelial neoplasia grade 2 or 3 (CIN<\/jats:styled-content> 2\/3) despite testing negative for HPV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective study was conducted at a university hospital in Barcelona, Spain, between March 2003 and January 2015 among women with abnormal cytology results according to the Bethesda classification system. All participants underwent HPV<\/jats:styled-content> testing, cytology, and colposcopy.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 1376 participants, 609 (44.3%) were diagnosed with CIN<\/jats:styled-content> 2\/3. Of these women, 74 (12.2%) tested negative for HPV<\/jats:styled-content>. Among 479 women with colposcopy\u2010guided biopsy sampling showing CIN<\/jats:styled-content> 2\/3, cone biopsy results that were negative for CIN<\/jats:styled-content> 2\/3 were more frequent among patients with negative HPV<\/jats:styled-content> testing (13\/61 [21.3%]) than among those with positive HPV<\/jats:styled-content> tests (58\/418 [13.9%]; P=<\/jats:italic>0.03). Additionally, among 59 patients diagnosed with cervical cancer, 9 (15.3%) tested negative for HPV<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The HPV<\/jats:styled-content> test was negative for 12% and 15% of patients diagnosed with biopsy\u2010proven CIN<\/jats:styled-content> 2\/3 and cervical cancer, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12030","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T04:43:47Z","timestamp":1484282627000},"page":"229-231","source":"Crossref","is-referenced-by-count":5,"title":["Negative HPV<\/scp> testing among patients with biopsy\u2010proven cervical intraepithelial neoplasia grade 2\/3 or cervical cancer"],"prefix":"10.1002","volume":"136","author":[{"given":"Eduardo","family":"Gonz\u00e1lez\u2010Bosquet","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Universitary Hospital Sant Joan de Deu Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Universitary Hospital Sant Joan de Deu Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Sabra","sequence":"additional","affiliation":[{"name":"Barcelona Center for Maternal Fetal and Neonatal Medicine Fetal i+D Fetal Medicine Research Center Hospital Clinic Hospital Sant Joan de Deu University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Lailla","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Universitary Hospital Sant Joan de Deu Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600688"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.12.450"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.04.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22688"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.06.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21955"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071430"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1998.00094.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2013.02.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/798710"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70230-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/DHPS.S37273"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3182909f86"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.09.013"}],"container-title":["International Journal of Gynecology & Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.12030","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.12030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T13:30:16Z","timestamp":1730208616000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.12030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,14]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1002\/ijgo.12030"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.12030","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"type":"print","value":"0020-7292"},{"type":"electronic","value":"1879-3479"}],"subject":[],"published":{"date-parts":[[2016,11,14]]}}}