{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:49:58Z","timestamp":1761490198002},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T00:00:00Z","timestamp":1480636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the pregnancy outcomes of couples containing a carrier of a reciprocal chromosome translocation (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>) after assisted reproductive technology without preimplantation genetic diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed using data for couples with an <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> carrier and control couples with a normal karyotype (1:4 ratio) who underwent assisted reproductive technology cycles at a Chinese fertility center in 2010\u20132011. The embryos were fertilized via <jats:italic>in vitro<\/jats:italic> fertilization (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>) or intracytoplasmic sperm injection (<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content>). Only the first pick\u2010up cycles were used for analysis. Clinical variables were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control group (n=164), the <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> group (n=41) had a marginally lower clinical pregnancy rate (46.3% [19\/41] vs 54.3% [89\/164]), implantation rate (21.7% [23\/106] vs 26.9% [118\/438]), multiple\u2010gestation pregnancy rate (21.1% [4\/19] vs 32.6% [29\/89]), and delivery rate (36.6% [15\/41] vs 47.6% [78\/164]), whereas the spontaneous abortion rate was slightly higher (21.1% [4\/19] vs 12.4% [11\/89]). However, none of these differences were significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical outcomes for <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> carriers were acceptable after <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ICSI<\/jats:styled-content> without performing preimplantation genetic diagnosis, indicating that this approach might comprise a feasible alternative fertility treatment for <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> carriers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12062","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T06:11:27Z","timestamp":1486534287000},"page":"304-308","source":"Crossref","is-referenced-by-count":6,"title":["Clinical outcomes for couples containing a reciprocal chromosome translocation carrier without preimplantation genetic 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