{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:17:09Z","timestamp":1762507029142},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,3]],"date-time":"2017-01-03T00:00:00Z","timestamp":1483401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate, from a gynecology perspective, the transition from cytology\u2010based <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> screening to primary <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Studies examining switching from cytology\u2010based screening to primary <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> testing with triaging of patients with positive test results were retrieved and reviewed, with a particular focus on screening in an Italian setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The increased complexity of patient\u2010management decisions when implementing <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010based screening was a critical issue discussed in the literature. The change in strategy represents a paradigm shift in moving from a medical perspective of identifying the disease in individual patients, to a public\u2010healthcare perspective of excluding <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> from the healthy population and identifying a small sub\u2010group of individuals at increased risk of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With knowledge about <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> screening evolving rapidly, new programs and related algorithms need to be sufficiently flexible to be adjusted according to ongoing research and the validation of new assays. The establishment of a national working group (including epidemiologists, gynecologists, pathologists, and healthcare providers) will be necessary to properly implement and govern this important technical and cultural transition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12065","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T06:11:27Z","timestamp":1486534287000},"page":"266-271","source":"Crossref","is-referenced-by-count":5,"title":["The clinical implementation of primary <scp>HPV<\/scp> screening"],"prefix":"10.1002","volume":"136","author":[{"given":"Luciano","family":"Mariani","sequence":"first","affiliation":[{"name":"HPV Unit Department of Gynecologic Oncology Regina Elena National Cancer Institute  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Igidbashian","sequence":"additional","affiliation":[{"name":"Preventive Gynaecology Unit European Institute of Oncology  Milan 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