{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:07:37Z","timestamp":1780589257299,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shanghai Advanced Integrated Traditional Chinese and Western Medicine Personnel Training Program","award":["ZY3-RCPY-4-2004"],"award-info":[{"award-number":["ZY3-RCPY-4-2004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The safety of laparoscopic surgery during the second trimester of pregnancy remains a controversial subject.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the safety of laparoscopic surgery and laparotomy for suspected adnexal mass during the second trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Articles published in any language prior to April 31, 2016, were retrieved from PubMed, Scopus, <jats:styled-content style=\"fixed-case\">EMBSCO<\/jats:styled-content>, and the Cochrane Library using keywords including pregnant, adnexal mass, laparoscopy, laparotomy, pregnancy outcomes, and surgical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Randomized and non\u2010randomized controlled trials reporting at least one obstetric or surgical outcome were included if they compared laparoscopic surgery and laparotomy for adnexal masses during the second trimester.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Data were independently extracted by two reviewers. Homogeneous data were pooled using a fixed effects model and heterogeneous data were qualitatively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>Four comparative effectiveness studies including a total of 240 patients were identified. Laparoscopic surgery was associated with a reduced risk of post\u2010operative adverse events (relative risk 0.20, 95% confidence interval 0.06\u20130.72); no difference was recorded in the risk of post\u2010operative spontaneous abortion (<jats:italic>P=<\/jats:italic>0.26) or threatened spontaneous abortion (<jats:italic>P=<\/jats:italic>0.13).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Laparoscopic surgery could be preferable to laparotomy for suspected adnexal mass during the second trimester of pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12069","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T06:11:27Z","timestamp":1486534287000},"page":"272-279","source":"Crossref","is-referenced-by-count":43,"title":["Meta\u2010analysis comparing the safety of laparoscopic and open surgical approaches for suspected adnexal mass during the second trimester"],"prefix":"10.1002","volume":"136","author":[{"given":"Yi\u2010Xuan","family":"Liu","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital Fudan University  Shanghai China"},{"name":"Department of Obstetrics and Gynecology Shanghai Medical College Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital Fudan University  Shanghai China"},{"name":"Department of Obstetrics and Gynecology Shanghai Medical 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