{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:08:00Z","timestamp":1783033680491,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T00:00:00Z","timestamp":1486684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of age on pre\u2010 and post\u2010conization <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotype distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present retrospective observational study included consecutive women with high\u2010grade cervical intraepithelial neoplasia who underwent conization at the Cervical Cancer Screening Centre of Reggio Emilia, Italy, and University Hospital of Modena, Italy, between February 1, 2012, and October 31, 2014. Pre\u2010conization and 6\u2010month post\u2010conization <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotyping results were compared between four age groups (&lt;30, 30\u201339, 40\u201349, and \u226550\u00a0years) and age\u2010related changes in the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotypes present were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 162 patients included. The lowest occurrence of pre\u2010conization high\u2010risk and probable high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotypes was observed among patients aged at least 50\u00a0years when compared with younger patients (<jats:italic>P=<\/jats:italic>0.017). Conversely, women aged at least 50\u00a0years exhibited the highest level of post\u2010conization high\u2010risk and probable high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotypes (<jats:italic>P=<\/jats:italic>0.043). Additionally, an increasing incidence of recording identical pre\u2010 and post\u2010conization <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotypes was associated with increasing age (<jats:italic>P=<\/jats:italic>0.024), as was increasing post\u2010treatment recurrence of cervical intraepithelial neoplasia grade 2+ (<jats:italic>P=<\/jats:italic>0.030).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of high\u2010risk and probable high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotypes was lowest among older patients before conization and was highest among these patients post\u2010conization; post\u2010treatment <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> clearance decreased with age and increasing age could be a risk factor for post\u2010conization recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12106","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T21:37:54Z","timestamp":1485553074000},"page":"72-77","source":"Crossref","is-referenced-by-count":20,"title":["Age\u2010related changes in pre\u2010 and post\u2010conization <scp>HPV<\/scp> genotype distribution among women with high\u2010grade cervical intraepithelial neoplasia"],"prefix":"10.1002","volume":"137","author":[{"given":"Luca","family":"Giannella","sequence":"first","affiliation":[{"name":"Local Health Authority of Reggio Emilia Division of Obstetrics and Gynecology Cesare Magati Hospital  Scandiano Italy"},{"name":"Cervical Cancer Screening Centre IRCCS\u2010Arcispedale Santa Maria Nuova  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fodero","sequence":"additional","affiliation":[{"name":"Cervical Cancer Screening Centre IRCCS\u2010Arcispedale Santa Maria Nuova  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