{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:18:07Z","timestamp":1762867087136},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the efficiency of pre\u2010implantation genetic screening (<jats:styled-content style=\"fixed-case\">PGS<\/jats:styled-content>) among women scheduled to undergo intracytoplasmic sperm injection who had experienced recurrent in vitro fertilization (<jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content>) failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present retrospective cohort study reviewed the medical records of consecutive women who had experienced recurrent <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> failure and had presented at a private <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> facility in Trabzon Province, Turkey, to undergo intracytoplasmic sperm injection between May 1, 2012, and December 31, 2014. Patient data and perinatal outcomes were compared between patients who underwent <jats:styled-content style=\"fixed-case\">PGS<\/jats:styled-content> and those who did not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 88 patients included in the study; 43 patients had undergone <jats:styled-content style=\"fixed-case\">PGS<\/jats:styled-content> and 45 had declined to do so. No differences were detected in the clinical pregnancy rate (<jats:italic>P<\/jats:italic>=0.846), spontaneous abortion rate (<jats:italic>P<\/jats:italic>=0.416), number of perinatal deaths (<jats:italic>P<\/jats:italic>=0.162), or the number of live deliveries (<jats:italic>P<\/jats:italic>=0.188) between the groups of patients. The pregnancies included in the study resulted in 25 neonates being delivered; 24 had normal karyotypes, and one neonate from the control group had a karyotype of 46, <jats:styled-content style=\"fixed-case\">XX<\/jats:styled-content>, 9ph. Among the 19 embryos that were not transferred, the most frequently encountered chromosomal anomalies were diploidy, monosomy X, and 2N\/N\/4N mosaicism, detected in 7 (37%), 2 (11%), and 2 (11%) embryos, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PGS<\/jats:styled-content> had no effect on perinatal outcomes among women experiencing recurrent <jats:styled-content style=\"fixed-case\">IVF<\/jats:styled-content> failure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12135","type":"journal-article","created":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T02:36:37Z","timestamp":1488594997000},"page":"314-318","source":"Crossref","is-referenced-by-count":13,"title":["Pre\u2010implantation genetic screening among women experiencing recurrent failure of in vitro fertilization"],"prefix":"10.1002","volume":"137","author":[{"given":"Safak","family":"Hatirnaz","sequence":"first","affiliation":[{"name":"Private Bilge Hospital Kucukkoy, Gaziosmanpasa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev","family":"Ozer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kahramanmaras Sutcu Imam University Hospital Kahramanmaras Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Hatirnaz","sequence":"additional","affiliation":[{"name":"Private Bilge Hospital Kucukkoy, Gaziosmanpasa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melahat","family":"Atasever","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Giresun University Hospital Giresun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serdar","family":"Ba\u015faranoglu","sequence":"additional","affiliation":[{"name":"Private Bilge Hospital Kucukkoy, Gaziosmanpasa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine","family":"Kanat\u2010Pektas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kocatepe University Hospital Afyon Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Api","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aydin University Hospital Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.04.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1068752"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/SO100-720320140004963"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4B6395.2005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-789-1_20"},{"key":"e_1_2_7_7_1","first-page":"CD005291","article-title":"Preimplantation genetic screening for abnormal number of chromosomes (aneuploidies) in in vitro fertilisation or intracytoplasmic sperm injection","author":"Twisk M","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.12.2673"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr052"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev122"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2015.01.011"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02072535"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00500631"},{"key":"e_1_2_7_14_1","first-page":"150","article-title":"Chromosome abnormalities in human arrested pre\u2010implantation embryos: A multiple\u2010probe FISH study","volume":"55","author":"Munn\u00e9 S","year":"1994","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61735-X"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61938-4"},{"key":"e_1_2_7_17_1","first-page":"726","article-title":"Pre\u2010implantation genetic diagnosis: A preliminary report of 2\u00a0years of experience","volume":"27","author":"Chen CK","year":"2004","journal-title":"Chang Gung Med J"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026232625659"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390051030"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/6.11.1055"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.09.082"}],"container-title":["International Journal of Gynecology &amp; 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