{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:35:47Z","timestamp":1789421747833,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401273"],"award-info":[{"award-number":["81401273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20140276"],"award-info":[{"award-number":["BK20140276"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess circulating levels of transforming growth factor (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>)\u2010\u03b2 superfamily members and their soluble receptors in hypertensive disorders of pregnancy, and to investigate associations with clinical manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was conducted using data for women admitted to a center in China for delivery between May 2011 and April 2013. Women with severe pre\u2010eclampsia, mild pre\u2010eclampsia, and gestational hypertension were included, along with a control group. Serum levels of activin A, inhibin A, <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21, soluble endoglin (<jats:styled-content style=\"fixed-case\">sE<\/jats:styled-content>ng), and soluble betaglycan (<jats:styled-content style=\"fixed-case\">sBG<\/jats:styled-content>) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with severe pre\u2010eclampsia (n\u00a0=\u00a017) had higher mean levels of activin\u00a0A (23.5\u00b12.1\u00a0\u03bcg\/L), inhibin\u00a0A (1.7\u00b10.2\u00a0\u03bcg\/L), <jats:styled-content style=\"fixed-case\">sE<\/jats:styled-content>ng (32.1\u00b13.2\u00a0\u03bcg\/L), and <jats:styled-content style=\"fixed-case\">sBG<\/jats:styled-content> (84.1\u00b19.4\u00a0\u03bcg\/L) than did normotensive controls (n\u00a0=\u00a018), women with gestational hypertension (n\u00a0=\u00a015), and those with mild pre\u2010eclampsia (n\u00a0=\u00a014; all <jats:italic>P<\/jats:italic>&lt;0.05). Women with early\u2010onset pre\u2010eclampsia (n\u00a0=\u00a013) had higher levels of these serum markers than did preterm normotensive controls (n\u00a0=\u00a08; all <jats:italic>P<\/jats:italic>&lt;0.001). Women with severe or early\u2010onset pre\u2010eclampsia had the lowest <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21 levels. Activin A, inhibin A, <jats:styled-content style=\"fixed-case\">sE<\/jats:styled-content>ng, and <jats:styled-content style=\"fixed-case\">sBG<\/jats:styled-content> levels were positively correlated with mean arterial pressure and proteinuria (all <jats:italic>P<\/jats:italic>&lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pre\u2010eclampsia is associated with an imbalance of members of the <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 superfamily and their soluble receptors, which might contribute to the development of pre\u2010eclampsia and help to predict onset and severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12142","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T02:26:36Z","timestamp":1489112796000},"page":"246-252","source":"Crossref","is-referenced-by-count":21,"title":["Maternal circulating levels of transforming growth factor\u2010\u03b2 superfamily and its soluble receptors in hypertensive disorders of pregnancy"],"prefix":"10.1002","volume":"137","author":[{"given":"Yan\u2010ting","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010hong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai\u2010ying","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Human Reproduction and Genetics Suzhou Municipal Hospital  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Human Reproduction and Genetics Suzhou Municipal Hospital  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"330","article-title":"ACOG practice bulletin on diagnosing and managing preeclampsia and eclampsia. American College of Obstetricians and Gynecologists","volume":"66","author":"Schroeder BM","year":"2002","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-2-53"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2004.03.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056754"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09264-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.7.1640"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8800"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/35006129"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.01076"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzn023"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.6.627"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3150815"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1429"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055352"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004453"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343220"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1550"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91324-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1450505"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097632"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2349"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2203"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2009.02453.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2012.02.006"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.348"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.12142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.12142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:14:12Z","timestamp":1696392852000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.12142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,31]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1002\/ijgo.12142"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.12142","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,31]]}}}