{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:14:44Z","timestamp":1762161284588},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["105\u2010S3054"],"award-info":[{"award-number":["105\u2010S3054"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To identify risk factors associated with treatment failure among women with cesarean scar pregnancy (CSP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>In a retrospective study, the medical records of patients with CSP<\/jats:styled-content> treated at National Taiwan University Hospital, Taipei, Taiwan, from 1994 to 2015 were reviewed. The women were managed primarily with hysterotomy, evacuation, or methotrexate. Receiver operating characteristic (ROC<\/jats:styled-content>) curve analysis and logistic regression analysis were used to evaluate the factors associated with treatment failure.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 90 patients, 44 underwent hysterotomy, 18 underwent evacuation, and 28 received methotrexate. The success rates were 100% (44\/44) for hysterotomy, 83% (15\/18) for evacuation, and 57% (16\/28) for methotrexate (P<<\/jats:italic>0.001). ROC<\/jats:styled-content> curve analysis indicated that a pregnancy length of 8\u00a0weeks and a mean sac diameter (MSD<\/jats:styled-content>) of 4\u00a0cm were both predictive of failure of treatment by primary evacuation and methotrexate. In multivariate logistic regression analysis, an MSD<\/jats:styled-content> of 4\u00a0cm or more was the only independent risk factor for treatment failure (odds ratio 68.99, 95% confidence interval 6.27\u2013759.60; P=<\/jats:italic>0.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Primary hysterotomy was suitable for treatment of CSP<\/jats:styled-content> of any size. Failure of primary evacuation or methotrexate usually occurred when the MSD<\/jats:styled-content> was larger than 4\u00a0cm.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12157","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T14:42:45Z","timestamp":1490020965000},"page":"28-36","source":"Crossref","is-referenced-by-count":12,"title":["Risk factors associated with failure of treatment for cesarean scar pregnancy"],"prefix":"10.1002","volume":"138","author":[{"given":"Ying\u2010Cheng","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology National Taiwan University Hospital National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010An","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Taiwan University Hospital National Taiwan University College of Medicine Taipei 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