{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T16:02:22Z","timestamp":1768147342887,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:00:00Z","timestamp":1492646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vaginal progesterone and 17\u03b1\u2010hydroxyprogesterone (17\u03b1\u2010<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>) are both used to prevent preterm delivery in women who have experienced spontaneous preterm delivery (<jats:styled-content style=\"fixed-case\">SPTD<\/jats:styled-content>) previously. Randomized trial data of the comparative effectiveness of these interventions have been mixed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy of intramuscular 17\u03b1\u2010<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content> and vaginal progesterone in the prevention of recurrent <jats:styled-content style=\"fixed-case\">SPTD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search strategy<\/jats:title><jats:p>Cochrane Central Register of Controlled Trials, African Journals Online, Embase, Google Scholar, <jats:styled-content style=\"fixed-case\">ISI<\/jats:styled-content> Web of Science, <jats:styled-content style=\"fixed-case\">LILACS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CINAHL<\/jats:styled-content>, PubMed, and registers of ongoing trials were searched using keywords related to 17\u03b1\u2010<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>, vaginal progesterone, and preterm delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection criteria<\/jats:title><jats:p>Randomized controlled trials published between January 1, 1966, and November 30, 2016, comparing 17\u03b1\u2010<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content> and vaginal progesterone for the prevention of recurrent <jats:styled-content style=\"fixed-case\">SPTD<\/jats:styled-content> during singleton pregnancies were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data collection and analysis<\/jats:title><jats:p>Study data were extracted and meta\u2010analyses were performed when outcomes were comparable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main results<\/jats:title><jats:p>The meta\u2010analyses included data from three randomized trials. Lower rates of <jats:styled-content style=\"fixed-case\">SPTD<\/jats:styled-content> before 34\u00a0weeks (relative risk 0.71, 95% confidence interval 0.53\u20130.95) and before 32\u00a0weeks (relative risk 0.62, 95% confidence interval 0.40\u20130.94) of pregnancy were observed among patients treated with vaginal progesterone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vaginal progesterone and 17\u03b1\u2010<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content> were comparable for the prevention of recurrent <jats:styled-content style=\"fixed-case\">SPTD<\/jats:styled-content> in singleton pregnancies; vaginal progesterone could be superior.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ijgo.12166","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T17:07:30Z","timestamp":1490980050000},"page":"12-16","source":"Crossref","is-referenced-by-count":15,"title":["Meta\u2010analysis of randomized controlled trials comparing 17\u03b1\u2010hydroxyprogesterone caproate and vaginal progesterone for the prevention of recurrent spontaneous preterm delivery"],"prefix":"10.1002","volume":"138","author":[{"given":"Elizabeth","family":"Oler","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahizechukwu C.","family":"Eke","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Hesson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Michigan School of Medicine  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Centers for Disease Control and Prevention National Center for Health Statistics National Vital Statistics System births: Final data for 2013","volume":"64","author":"Martin JA","year":"2015","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0860"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035140"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31818b1ff6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067815"},{"key":"e_1_2_7_8_1","first-page":"1301","article-title":"Comparative Study of Vaginal versus Intramuscular Progesterone in the Prevention of Preterm Delivery: A Randomized Clinical Trial","volume":"7","author":"Bafghi AS","year":"2015","journal-title":"Electron Physician"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2016.01.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00136"},{"key":"e_1_2_7_12_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Higgins JPT","year":"2011"},{"key":"e_1_2_7_13_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Deeks JJ","year":"2011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijgo.12166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.12166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T08:55:20Z","timestamp":1714812920000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.12166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,20]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/ijgo.12166"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.12166","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,20]]}}}