{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:36Z","timestamp":1791528576232,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:00:00Z","timestamp":1501804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:00:00Z","timestamp":1501804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the risk of adverse pregnancy outcomes in subsequent pregnancies among women treated with methotrexate for ectopic pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a retrospective single\u2010center study, data were assessed for women treated with methotrexate for ectopic pregnancy at Asaf Harofe Medical Center, Zerifin, Israel, between May 2004 and May 2014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 226 women were treated with methotrexate for ectopic pregnancy and subsequently conceived. The median time from treatment to conception was 10\u00a0months (range 1\u2013120\u00a0months), and 127 women conceived within 12\u00a0months of treatment. Except for early missed abortion\u2014which affected 23 (10.2%) pregnancies\u2014adverse pregnancy outcomes such as fetal malformations were rare. The frequency of early abortion was lowest for women who conceived within 6\u00a0months of treatment with methotrexate (3\/93, 3.2%), increased between 6 and 23\u00a0months (15\/83, 18.1%), and remained high thereafter (7\/50, 14.0%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The frequency of fetal malformation in a subsequent pregnancy was low among women treated with methotrexate for ectopic pregnancy. The frequency of early missed abortion was lowest during the first 6\u00a0months after treatment with methotrexate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.12264","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T03:06:52Z","timestamp":1500088012000},"page":"170-173","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of conception subsequent to methotrexate treatment for an unruptured ectopic pregnancy"],"prefix":"10.1002","volume":"139","author":[{"given":"Ran","family":"Svirsky","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Assaf Harofeh Medical Center  Zerifin Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Ben\u2010Ami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Assaf Harofeh Medical Center  Zerifin Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matitiahu","family":"Berkovitch","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Clinical Pharmacology Unit Assaf Harofeh Medical Center  Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuvit","family":"Halperin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Assaf Harofeh Medical Center  Zerifin Israel"},{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Rozovski","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Institute of Hematology Davidoff Cancer Center Beilinson Hospital  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.04.023"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70219-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90687-E"},{"key":"e_1_2_7_5_1","first-page":"754","article-title":"Single\u2010dose methotrexate for treatment of ectopic pregnancy","volume":"77","author":"Stovall TG","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-2929-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150110"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36625"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/92.10.551"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38368"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196003\/04)13:2<241::AID-CNCR2820130206>3.0.CO;2-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2008.11.055"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn012"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.002"},{"key":"e_1_2_7_15_1","first-page":"2360","article-title":"Low dose methotrexate in the first trimester of pregnancy: Results of a French collaborative study","volume":"31","author":"Lewden B","year":"2004","journal-title":"J\u00a0Rheumatol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420490202"}],"container-title":["International Journal of Gynecology &amp; 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